{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:32:26Z","timestamp":1783607546298,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Age\u2010related functional decline in muscle strength is a major determinant of disability in older adults. Although kidney dysfunction has been implicated in sarcopenia, longitudinal evidence linking changes in kidney function with muscle strength decline in community\u2010dwelling older adults remains limited. This study, part of the Kusatsu Cohort Study, aimed to examine whether 6\u2010year changes in estimated glomerular filtration rate (eGFR) were associated with changes in handgrip strength and skeletal muscle mass index (SMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 279 residents in Kusatsu Town, Gunma Prefecture, aged \u2265\u200965\u2009years participated in municipal checkups in 2019, 2021, 2023, and 2025. Handgrip strength, SMI, and eGFR (uncorrected for body surface area) were assessed. Six\u2010year changes (\u0394grip, \u0394SMI, \u0394eGFR) were calculated. Associations were examined using Pearson correlation and multivariable linear regression. ROC analysis evaluated the discriminatory ability of \u0394eGFR for grip\u2010strength decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Grip strength declined significantly over 6\u2009years (28.5\u2009\u00b1\u20098.8\u201324.0\u2009\u00b1\u20097.6\u2009kg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas SMI remained stable (6.3\u2009\u00b1\u20091.0 to 6.2\u2009\u00b1\u20091.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.10). \u0394grip correlated positively with \u0394eGFR (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In multivariable analysis, \u0394eGFR independently predicted \u0394grip (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), along with sex and baseline grip strength. ROC analysis showed moderate discrimination (AUC 0.664), with an optimal \u0394eGFR cutoff of \u22120.263 over 6\u2009years (\u22124.4%\/year).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preservation of kidney function was independently associated with a smaller decline in handgrip strength among community\u2010dwelling older adults. These findings highlight kidney\u2013muscle crosstalk as a key mechanism of functional aging and support the use of eGFR decline as a biomarker for early detection of strength deterioration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70605","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:25:06Z","timestamp":1781681106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal Association Between Kidney Function Decline and Grip Strength Loss in Community\u2010Dwelling Older Adults: A 6\u2010Year Prospective Cohort Study"],"prefix":"10.1111","volume":"26","author":[{"given":"Kaoruko","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Yatabe","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Taito","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Izawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Matsuno","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4131-6151","authenticated-orcid":false,"given":"Seiji","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6804-3947","authenticated-orcid":false,"given":"Takayuki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Research Team for Social Participation and Community Health Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Nofuji","sequence":"additional","affiliation":[{"name":"Research Team for Social Participation and Community Health Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-7763","authenticated-orcid":false,"given":"Hiroshi","family":"Murayama","sequence":"additional","affiliation":[{"name":"Research Team for Social Participation and Community Health Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Shinkai","sequence":"additional","affiliation":[{"name":"Department of Nutrition Graduate School of Kagawa Nutrition University  Sakado Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0675-5075","authenticated-orcid":false,"given":"Mitsuyo","family":"Itabashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6283-8146","authenticated-orcid":false,"given":"Takashi","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis Tokyo Metropolitan Institute for Geriatrics and Gerontology  Itabashi City Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S194543"},{"key":"e_1_2_11_3_1","first-page":"M446","article-title":"Handgrip Strength and Mortality in Older Adults","volume":"58","author":"Rantanen T.","year":"2003","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"e_1_2_11_4_1","first-page":"331","article-title":"Objectively Measured Physical Capability Levels and Mortality","volume":"39","author":"Cooper R.","year":"2010","journal-title":"Age and Ageing"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201001004\u2010y"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012070702"},{"key":"e_1_2_11_7_1","first-page":"287","article-title":"Muscle Wasting in CKD","volume":"85","author":"Isoyama N.","year":"2014","journal-title":"Kidney International"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.112"},{"key":"e_1_2_11_9_1","first-page":"219","article-title":"Uremic Myopathy","volume":"25","author":"Fahal I. H.","year":"2015","journal-title":"Journal of Renal Nutrition"},{"key":"e_1_2_11_10_1","first-page":"1564","article-title":"Association Between eGFR and Muscle Strength in Older Adults","volume":"31","author":"Hirai K.","year":"2016","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"e_1_2_11_11_1","first-page":"1234","article-title":"Kidney Function and Muscle Strength in Community\u2010Dwelling Older Adults","volume":"62","author":"Yoshida D.","year":"2014","journal-title":"Journal of the American Geriatrics Society"},{"key":"e_1_2_11_12_1","first-page":"181","article-title":"Prevalence and Clinical Implications of Sarcopenia in CKD","volume":"29","author":"Kim T. N.","year":"2014","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12726"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20180076"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_11_17_1","first-page":"1017","article-title":"Mitochondrial Dysfunction and Muscle Energetics in CKD","volume":"82","author":"Gamboa J. L.","year":"2012","journal-title":"Kidney International"},{"key":"e_1_2_11_18_1","first-page":"361","article-title":"Energetics and Muscle Performance in CKD","volume":"26","author":"Roshanravan B.","year":"2017","journal-title":"Current Opinion in Nephrology and Hypertension"},{"key":"e_1_2_11_19_1","first-page":"212","article-title":"Inflammation in CKD","volume":"372","author":"Stenvinkel P.","year":"2008","journal-title":"Lancet"},{"key":"e_1_2_11_20_1","first-page":"C1390","article-title":"Acidosis and Muscle Proteolysis","volume":"271","author":"Bailey J. L.","year":"1996","journal-title":"American Journal of Physiology"},{"key":"e_1_2_11_21_1","first-page":"923","article-title":"Myostatin and CKD\u2010Related Muscle Wasting","volume":"80","author":"Zhang L.","year":"2011","journal-title":"Kidney International"},{"key":"e_1_2_11_22_1","first-page":"1917","article-title":"FGF23 and Physical Function","volume":"22","author":"Ix J. H.","year":"2011","journal-title":"Journal of the American Society of Nephrology"},{"key":"e_1_2_11_23_1","first-page":"349","article-title":"IGF\u20101 and Muscle Function in CKD","volume":"25","author":"Cordeiro A. C.","year":"2010","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"e_1_2_11_24_1","first-page":"815","article-title":"Neuromuscular Aging","volume":"34","author":"Deschenes M. R.","year":"2004","journal-title":"Sports Medicine"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.10.1059"},{"key":"e_1_2_11_27_1","first-page":"412","article-title":"Muscle Quality and Aging","volume":"18","author":"McGregor R. A.","year":"2014","journal-title":"Journal of Nutrition, Health & Aging"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.8.829"},{"key":"e_1_2_11_29_1","first-page":"1127","article-title":"Decline in eGFR and Risk of Adverse Outcomes","volume":"371","author":"Coresh J.","year":"2014","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_11_30_1","first-page":"B143","article-title":"Midlife Hand Grip Strength as a Predictor of Old Age Disability","volume":"53","author":"Rantanen T.","year":"1998","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"e_1_2_11_31_1","first-page":"531","article-title":"Grip Strength Across the Life Course: Normative Data","volume":"43","author":"Dodds R. M.","year":"2014","journal-title":"Age and Ageing"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.5.B209"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.70605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ggi.70605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.70605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:08:36Z","timestamp":1782302916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.70605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ggi.70605"],"URL":"https:\/\/doi.org\/10.1111\/ggi.70605","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70605"}}