{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:44:44Z","timestamp":1788799484894,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia and osteoporosis are common age\u2010related conditions that lead to frailty, functional decline, and increased fracture risk. Resistance training (RT) improves muscle strength and bone mineral density (BMD), but the optimal training intensity remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis synthesized evidence from randomized controlled trials evaluating high\u2010intensity (\u2265\u200970% one\u2010repetition maximum) versus low\u2010to\u2010moderate\u2010intensity (&lt;\u200970% one\u2010repetition maximum) RT in older adults (age\u2009\u2265\u200950\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The review included 18 studies (1283 participants). The primary outcomes were lower limb muscle strength (leg press and leg extension), lumbar spine BMD, and femoral neck BMD. The secondary outcomes were fall incidence and adverse events. Standardized mean differences (SMDs) and risk ratios (RRs) were pooled using a random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High\u2010intensity RT significantly outperformed low\u2010to\u2010moderate\u2010intensity RT in improving leg press (SMD: 0.95; 95% confidence interval [CI]: 0.48\u20131.43) and leg extension (SMD: 0.63; 95% CI: 0.09\u20131.17). No significant between\u2010regimen difference was observed in lumbar spine BMD (SMD: 0.28; 95% CI: \u22120.02 to 0.58), femoral neck BMD (SMD: 0.13; 95% CI: \u22120.08 to 0.33), fall incidence (RR: 2.68; 95% CI: 0.65\u201311.11), or adverse events (RR: 2.42; 95% CI: 0.66\u20138.88).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High\u2010intensity RT outperforms low\u2010to\u2010moderate\u2010intensity RT in improving lower limb muscle strength in older adults. The modalities appear similarly effective in maintaining BMD. No significant between\u2010regimen differences were observed in fall incidence or adverse events, suggesting similar safety profiles. Further randomized controlled trials with well\u2010defined populations and standardized RT protocols are required to validate these findings.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      International Prospective Register of Systematic Reviews Database: CRD420251076841\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70607","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:41:57Z","timestamp":1782711717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of High\u2010Intensity Versus Low\u2010To\u2010Moderate\u2010Intensity Resistance Training in Improving Muscle Strength and Bone Mineral Density in Older Adults: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7918-272X","authenticated-orcid":false,"given":"Yu\u2010Chun","family":"Shen","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"},{"name":"Department of General Medicine Shuang\u2010Ho Hospital, Taipei Medical University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-482X","authenticated-orcid":false,"given":"Kee\u2010Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Cochrane Taiwan; Taipei Medical University  Taipei Taiwan"},{"name":"Post\u2010Baccalaureate Program in Nursing, College of Nursing, Taipei Medical University  Taipei Taiwan"},{"name":"Department of Nursing Wan Fang Hospital, Taipei Medical University  Taipei Taiwan"},{"name":"Research Center in Nursing Clinical Practice, Wan Fang Hospital; Taipei Medical University  Taipei Taiwan"},{"name":"Evidence\u2010Based Knowledge Translation Center, Wan Fang Hospital; Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hsuan","family":"Hou","sequence":"additional","affiliation":[{"name":"Cochrane Taiwan; Taipei Medical University  Taipei Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010No","family":"Kang","sequence":"additional","affiliation":[{"name":"Cochrane Taiwan; Taipei Medical University  Taipei Taiwan"},{"name":"Research Center of Big Data and Meta\u2010Analysis, Taipei Municipal Wan\u2010Fang Hospital  Cochrane Taiwan"},{"name":"National Taiwan University, Institute of Health Policy and Management  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2895-2648","authenticated-orcid":false,"given":"Wen\u2010Ting","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh Dinh","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Histopathology Hai Phong University of Medicine and Pharmacy  Haiphong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Cochrane Taiwan; Taipei Medical University  Taipei Taiwan"},{"name":"Department of Public Health School of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-6553","authenticated-orcid":false,"given":"Chiehfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Cochrane Taiwan; 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