{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:16:52Z","timestamp":1787991412846,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n This study aimed to investigate the effects of the COVID\u201019 shutdown (ShD) on the health status of older patients by analyzing longitudinal blood test data and comparing the differences between those receiving outpatient care (OPC) versus home medical care (HMC).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective longitudinal observational study with repeated measurements included 402 patients aged \u2265\u200965\u2009years. Blood test data were collected at three time points: early pre\u2010ShD, late pre\u2010ShD, and during ShD. Changes between \u201cthe early and late pre\u2010ShD\u201d and \u201clate pre\u2010ShD and during ShD\u201d were compared. Subgroup analyses were performed on the OPC and HMC groups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n No significant laboratory changes were observed between the two pre\u2010ShD periods. In contrast, the transition from the late pre\u2010ShD period to the ShD period was associated with significant decreases in serum albumin, glycated hemoglobin (HbA1c), red blood cell counts, and lymphocyte counts, together with a significant increase in blood urea nitrogen (BUN). The HMC group demonstrated a more pronounced increase in BUN during the ShD period than the OPC group.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The COVID\u201019 ShD was associated with changes in several laboratory parameters, particularly those receiving home medical care. Although the observed increases in BUN and decreases in serum albumin and HbA1c may be compatible with changes in hydration and nutritional status, these findings should be interpreted cautiously because direct assessments were unavailable. Likewise, the reduction in HbA1c should be interpreted with caution because concurrent decreases in red blood cell counts may have influenced HbA1c.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ggi.70766","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:52:22Z","timestamp":1785934342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of the\n COVID<\/scp>\n \u201019 Shutdown on Blood Test of Older Patients Who Received Home or Outpatient Care: A Retrospective Longitudinal Observational Study With Repeated Measurements"],"prefix":"10.1111","volume":"26","author":[{"given":"Emiko","family":"Kurosawa","sequence":"first","affiliation":[{"name":"Division of Geriatric and Community Medicine, Faculty of Medicine Tohoku Medical and Pharmaceutical University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7042-3762","authenticated-orcid":false,"given":"Shigeto","family":"Mashiko","sequence":"additional","affiliation":[{"name":"Division of Geriatric and Community Medicine, Faculty of Medicine Tohoku Medical and Pharmaceutical University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8047-4606","authenticated-orcid":false,"given":"Katsutoshi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Division of Geriatric and Community Medicine, Faculty of Medicine Tohoku Medical and Pharmaceutical University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"10440","key":"e_1_2_9_2_1","first-page":"1989","article-title":"Demographics Collaborators. Global Age\u2010Sex\u2010Specific Mortality, Life Expectancy, and Population Estimates in 204 Countries and Territories and 811 Subnational Locations, 1950\u20132021, and the Impact of the COVID\u201019 Pandemic: A Comprehensive Demographic Analysis for the Global Burden of Disease Study 2021","volume":"403","author":"GBD","year":"2021","journal-title":"Lancet"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70653"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201092279\u2010z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0004600"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1272769"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad603"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-020-1501-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.47176\/mjiri.38.130"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0894-0959.2004.17603.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009647.pub2"},{"key":"e_1_2_9_12_1","first-page":"833","article-title":"The Relationship Between Volume Status, Hydration, and Radiographic Findings in the Diagnosis of Community\u2010Acquired Pneumonia","volume":"49","author":"Hash R. B.","year":"2000","journal-title":"Journal of Family Practice"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.08.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1681762"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102015\u2010007581"}],"container-title":["Geriatrics & Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.70766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ggi.70766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.70766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:43:10Z","timestamp":1787989390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.70766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/ggi.70766"],"URL":"https:\/\/doi.org\/10.1111\/ggi.70766","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70766"}}