{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:05:21Z","timestamp":1790766321811,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Injurious falls and low\u2010energy fractures after a simple fall cause substantial morbidity in older adults; observational brain\u2010structure associations are vulnerable to confounding and reverse causation. To test whether predicted regional cortical thickness or surface area causally influences falls and fractures after a simple fall, and to evaluate reverse causality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Bidirectional two\u2010sample Mendelian randomization used cortical morphology across 34 regions (&gt;\u200951\u2009000 Europeans). Outcomes were falls\/tendency to fall and simple\u2010fall fractures. Independent genome\u2010wide significant instruments (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20095\u2009\u00d7\u200910\n                      <jats:sup>\u22128<\/jats:sup>\n                      ) were clumped at\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.001 within a 10\u2009000\u2009kb window, retained if SNP\u2010level\n                      <jats:italic>F<\/jats:italic>\n                      statistics were &gt;\u200910, and analyzed using inverse\u2010variance weighted MR with sensitivity methods, pleiotropy\/directionality checks, and Benjamini\u2013Hochberg FDR correction. Estimated bone mineral density (eBMD) was explored as a potential mediator.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After FDR correction and pleiotropy screening, larger caudal anterior cingulate surface area was associated with lower odds of fracture resulting from a simple fall (OR 0.95, 95% CI 0.92\u20130.98; pFDR\u2009=\u20090.0159), whereas larger insula surface area was related to higher odds of fracture resulting from a simple fall (OR 1.05, 95% CI 1.02\u20131.08; pFDR\u2009=\u20090.0037). Associations with the broader falls\/tendency\u2010to\u2010fall phenotype were not robust. Reverse MR showed no evidence that falls or simple\u2010fall fractures altered cortical traits, and exploratory eBMD analyses did not support mediation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genetically predicted surface area in the caudal anterior cingulate and insula was associated with susceptibility to fractures resulting from simple falls. These findings require replication and functional validation before specific neurobiological mechanisms or clinical applications can be inferred.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70839","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:35:27Z","timestamp":1790764527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cortical Morphology and Susceptibility to Fall\u2010Related Fractures: A Bidirectional Mendelian Randomization Study"],"prefix":"10.1111","volume":"26","author":[{"given":"Xiao\u2010Ling","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nursing The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3115-3128","authenticated-orcid":false,"given":"Qing\u2010Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nursing The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Zhao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Nursing The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5315-1052","authenticated-orcid":false,"given":"Ying\u2010Zhuo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nursing The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7859-9484","authenticated-orcid":false,"given":"Yong\u2010Mei","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Nursing The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"10","key":"e_1_2_15_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnha.2024.100357","article-title":"Characteristics of Fragility Hip Fracture\u2010Related Falls in the Older Adults: A Systematic Review","volume":"28","author":"Lim S. 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