{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:03:43Z","timestamp":1790233423697,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>International anticholinergic burden scales may incompletely capture country\u2010specific prescribing patterns and drug availability. Although the Japanese Anticholinergic Risk Scale (JARS) reflects Japanese clinical practice, its prognostic relevance in poststroke patients remains unclear. We examined whether JARS was associated with functional outcomes across activities of daily living (ADL), cognition, swallowing, nutrition, and muscle strength in older patients after stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study enrolled consecutive patients aged \u2265\u200965\u2009years undergoing poststroke rehabilitation. Anticholinergic burden was assessed using JARS at admission. The primary outcome was Functional Independence Measure (FIM)\u2010motor at discharge. Secondary outcomes were FIM\u2010cognitive, Food Intake Level Scale, Geriatric Nutritional Risk Index (GNRI), and handgrip strength at discharge. Multivariable linear regression was performed for total JARS and, as an exploratory analysis, psychotropic drug\u2010derived JARS, with adjustment for relevant covariates.\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values were adjusted across the five outcomes using the Benjamini\u2013Hochberg false discovery rate (FDR) procedure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 747 patients (median age, 80.0\u2009years; 51% men), 484 (64.8%) had a JARS score of \u2265\u20091. Total JARS was not associated with discharge FIM\u2010motor score (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u20090.032, 95% CI \u22120.799 to 0.862), FIM\u2010cognitive score, FILS, or handgrip strength. However, higher total JARS was negatively associated with GNRI at discharge in the primary analysis (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u2009\u22120.603; 95% CI, \u22121.061 to \u22120.146; FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) although this association did not remain statistically significant in the modified\u2010JARS sensitivity analysis (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u2009\u22120.666; 95% CI, \u22121.179 to \u22120.154; FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.055). Psychotropic drug\u2010derived JARS was associated with lower FIM\u2010cognitive score (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u2009\u22120.800; 95% CI, \u22121.318 to \u22120.282; FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), but not with the other outcomes after FDR adjustment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>JARS was not associated with discharge ADL, swallowing, or muscle strength. A modest association with nutritional risk was observed in the primary analysis, although this finding should be interpreted cautiously because statistical significance was not retained in the modified\u2010JARS sensitivity analysis. Psychotropic drug\u2010derived JARS was associated with cognitive level. These findings support domain\u2010 and drug\u2010class\u2010specific interpretation of anticholinergic burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70842","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:39:31Z","timestamp":1789180771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Japanese Anticholinergic Risk Scale and Domain\u2010Specific Functional Outcomes in Older Poststroke Patients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5012-056X","authenticated-orcid":false,"given":"Ayaka","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-4179","authenticated-orcid":false,"given":"Yoshihiro","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20240260"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.04.019"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/20420986211016645"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2020.05.065"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-03820-6"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18372"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-021-00895-x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12617"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930221090347"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-022-01416-5"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.22036"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.31662\/jmaj.2026-0293"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.2490\/prm.20250022"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179572717711433"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2012.02.012"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14204251"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-022-02224-7"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.11336\/jjcrs.13.41"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7957825"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-025-06606-0"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.15001"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0718-5"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.2490\/prm.20200030"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14102121"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-024-01725-x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000258355.23810.c6"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/46.4.357"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90184-7"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.07.020"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.4.777"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.2490\/prm.20220025"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12113"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00738"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007392"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1419405"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-201540"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10821"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.789986"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10588"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2014.38.6.759"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-020-01081-z"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.11.005"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610223000844"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.7663"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1315"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-020-06550-2"},{"key":"e_1_2_13_49_1","first-page":"CD015196","article-title":"Anticholinergic Burden for Prediction of Cognitive Decline or Neuropsychiatric Symptoms in Older Adults With Mild Cognitive Impairment or Dementia","volume":"8","author":"Taylor\u2010Rowan M.","year":"2022","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70558"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.70842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ggi.70842","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.70842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:31:59Z","timestamp":1790231519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.70842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/ggi.70842"],"URL":"https:\/\/doi.org\/10.1111\/ggi.70842","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70842"}}