{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:56:25Z","timestamp":1790902585226,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To derive a compact plasma proteomic signature associated with incident dementia and evaluate the internal performance of the finalized score in UK Biobank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, we screened 2923 baseline Olink assays using Cox models adjusted for age, age squared, sex, and the first 10 genetic principal components. Proteins passing false\u2010discovery\u2010rate control underwent 2\u2010 and 5\u2010year landmark analyses, correlation\u2010based redundancy pruning, and repeated stability\u2010based feature selection. The finalized score was evaluated in basic and extended clinical models, a chronological subgroup performance assessment, proportional\u2010hazards testing, and landmark sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 36\u2009696 participants (mean age 56.84\u2009years; 591 incident dementia events; median follow\u2010up 15.73\u2009years), the final 11\u2010protein score was associated with incident dementia (hazard ratio per 1\u2010SD increase, 2.645; 95% confidence interval, 2.459\u20132.845) and increased Harrell's C\u2010index from 0.798 to 0.862. In the extended clinical cohort (23\u2009179 participants; 441 events), C\u2010index increased from 0.792 to 0.861. In the later chronological subset (6954 participants; 97 events), C\u2010index increased from 0.801 to 0.869. Associations persisted in the 2\u2010 and 5\u2010year landmark analyses, and no statistically significant score\u2010specific violation of the proportional\u2010hazards assumption was detected (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.105).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A broad plasma proteomic screen yielded a compact 11\u2010protein signature that was strongly associated with incident dementia and showed consistent internal performance after the score had been finalized. Independent external validation is required before clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70854","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:34:48Z","timestamp":1790901288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An 11\u2010Protein Plasma Proteomic Signature Associated With Incident Dementia Risk in the\n                    <scp>UK<\/scp>\n                    Biobank"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0562-8835","authenticated-orcid":false,"given":"Simin","family":"Yang","sequence":"first","affiliation":[{"name":"Neurosurgery Center, National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases in Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Neurosurgery Center, National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases in Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hehan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Clinical Pathology, Key Laboratory of Transplant Engineering and Immunology, West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongzong","family":"Yang","sequence":"additional","affiliation":[{"name":"Neurosurgery Center, National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases in Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Neurosurgery Center, National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases in Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital Southern Medical University  Guangzhou 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