{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:34:44Z","timestamp":1793072084121,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess whether longitudinal hypertension trajectories are associated with later frailty among middle\u2010aged and older Chinese adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed 6770 participants from the China Health and Retirement Longitudinal Study (CHARLS) with complete data from waves 1 to 4 after excluding implausible body mass index values. Hypertension trajectories across waves 1 to 3 were classified as persistent no hypertension, incident\/progressive hypertension, remission\/fluctuation hypertension, or persistent hypertension. Frailty index (FI) at wave 4 was the outcome. Multivariable linear regression, restricted cubic spline analyses, sensitivity analyses, and exploratory mediation analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with persistent no hypertension, incident\/progressive hypertension (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.013, 95% CI: 0.006\u20130.020), remission\/fluctuation hypertension (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.009, 95% CI: 0.003\u20130.015), and persistent hypertension (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.008, 95% CI: 0.002\u20130.014) were associated with higher FI. Baseline systolic and diastolic blood pressure were also positively associated with FI. Systolic blood pressure showed a nonlinear association. Sensitivity analyses were broadly consistent. Exploratory mediation analyses suggested that cystatin C and C\u2010reactive protein partly mediated the persistent hypertension\u2013FI association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dynamic hypertension patterns and higher baseline blood pressure were associated with greater subsequent frailty burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70860","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:51:49Z","timestamp":1791431509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypertension Trajectories and Frailty Among Middle\u2010Aged and Older Chinese Adults: A\n                    <scp>CHARLS<\/scp>\n                    Cohort Study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2865-9666","authenticated-orcid":false,"given":"Ying","family":"Pi","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Hongdu Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Chinese Medicine  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hongdu Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Chinese Medicine  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hongdu Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Chinese Medicine  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hongdu Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Chinese Medicine  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqiong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hongdu Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Chinese Medicine  Nanchang Jiangxi 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