{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:53:25Z","timestamp":1791975205655,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ek0109622h0001"],"award-info":[{"award-number":["JP23ek0109622h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24ek0109622h0002"],"award-info":[{"award-number":["JP24ek0109622h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25ek0109622h0003"],"award-info":[{"award-number":["JP25ek0109622h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP26ek0109866h0001"],"award-info":[{"award-number":["JP26ek0109866h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA210916"],"award-info":[{"award-number":["R01CA210916"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n This study compared metabolic dysfunction\u2010associated steatotic liver disease (MASLD) in individuals with Werner syndrome (WS) and individuals with insulin\u2010resistant type 2 diabetes (T2D). It also examined the association with imaging findings of MASLD in individuals with WS, clarified the characteristics of MASLD that accompany WS, and identified useful indices for its diagnosis in addition to imaging.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Three hepatic steatosis and two hepatic fibrosis indices in 48 individuals enrolled in the Japanese Werner Syndrome Registry were compared with those in 101 Japanese individuals with insulin\u2010resistant T2D from another clinical study. In individuals with WS, the liver\/spleen ratio (L\/S ratio) was calculated from computed tomography (CT) images, and its associations with each index were examined. Statistical analyses were performed using the Welch test and pairwise comparisons.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Individuals with WS had lower hepatic steatosis and fibrosis index values than those with insulin\u2010resistant T2D. The mean L\/S ratio calculated from CT images was 1.05\u2009\u00b1\u20090.24 in individuals with WS. The L\/S ratio, which is one of the indicators for diagnosing MASLD, was <\u20090.9 in 5 of 20 cases (25%). Among the various indices in individuals with WS, only the hepatic steatosis index (HSI) was correlated with the L\/S ratio (\n r<\/jats:italic>\n \u2009=\u2009\u22120.863,\n p<\/jats:italic>\n \u2009=\u20090.0003).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The prevalence of MASLD is lower in individuals with WS than in those with insulin\u2010resistant T2D. The HSI was associated with the L\/S ratio in individuals with WS, suggesting that HSI may reflect hepatic steatosis\u2010related changes in this population. Further studies in larger cohorts are needed to validate these findings.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n The study was registered at the UMIN Clinical Trial Registry (\n https:\/\/upload.umin.ac.jp\/cgi\u2010open\u2010bin\/ctr_e\/ctr_view.cgi?recptno=R000034058<\/jats:ext-link>\n ) on November 3, 2017 (ID: UMIN000029812)\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ggi.70866","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:35:04Z","timestamp":1791974104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Metabolic Dysfunction\u2010Associated Steatotic Liver Disease Between Individuals With Werner Syndrome and Those With Insulin\u2010Resistant Type 2 Diabetes: Hepatic Steatosis and Fibrosis Indices"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3005-6473","authenticated-orcid":false,"given":"Makoto","family":"Miyabayashi","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Gerontology Chiba University Graduate School of Medicine Chiba Japan"},{"name":"Department of Diabetes, Metabolism and Endocrinology Chiba University Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-9993","authenticated-orcid":false,"given":"Masaya","family":"Koshizaka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Gerontology Chiba University Graduate School of Medicine Chiba Japan"},{"name":"Department of Nutrition and Metabolic Medicine, Center for Preventive Medical Sciences Chiba University Chiba 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Radiology and Radiation Oncology Chiba University Graduate School of Medicine Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-337X","authenticated-orcid":false,"given":"Akiko","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-0669","authenticated-orcid":false,"given":"Sei\u2010Ichiro","family":"Motegi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi 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A Narrative Review","volume":"80","author":"Zachou M.","year":"2024","journal-title":"European Journal of Clinical Pharmacology"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"24940","DOI":"10.18632\/aging.202441","article-title":"Time Gap Between the Onset and Diagnosis in Werner Syndrome: A Nationwide Survey and the 2020 Registry in Japan","volume":"12","author":"Koshizaka M.","year":"2020","journal-title":"Aging"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.18632\/aging.204681","article-title":"Renal Dysfunction, Malignant Neoplasms, Atherosclerotic Cardiovascular Diseases, and Sarcopenia as Key Outcomes Observed in a Three\u2010Year Follow\u2010Up Study Using the Werner Syndrome Registry","volume":"15","author":"Maeda Y.","year":"2023","journal-title":"Aging"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1111\/dom.16198","article-title":"Effects of the SGLT2 Inhibitor Ipragliflozin and Metformin on Hepatic Steatosis and Liver Fibrosis: Sub\u2010Analysis of a Randomized Controlled Study","volume":"27","author":"Hirayama K.","year":"2025","journal-title":"Diabetes, Obesity & Metabolism"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","DOI":"10.1186\/1471-230X-6-33","article-title":"The Fatty Liver Index: A Simple and Accurate Predictor of Hepatic Steatosis in the General Population","volume":"6","author":"Bedogni G.","year":"2006","journal-title":"BMC Gastroenterology"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.dld.2009.08.002","article-title":"Hepatic Steatosis Index: A Simple Screening Tool Reflecting Nonalcoholic Fatty Liver Disease","volume":"42","author":"Lee J. 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