{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:51:06Z","timestamp":1791939066204,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Muscle health is a clinically relevant dimension of vulnerability in older post\u2010stroke patients, but its gut microbial correlates remain unclear. We examined whether a taxonomy\u2010based putative butyrate\u2010producing gut bacteria profile was associated with admission muscle health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This registry\u2010based cross\u2010sectional study included patients aged 65\u2009years or older with 16S rRNA gut microbiota data and no systemic antibiotic exposure within 4\u2009weeks before stool sampling. A six\u2010genera profile was constructed from genus\u2010level relative abundance using centered log\u2010ratio transformation, standardization, and averaging. Outcomes were handgrip strength, skeletal muscle mass index (SMI), body mass index\u2010indexed appendicular skeletal muscle mass (ASM\/BMI), and sarcopenia by Asian Working Group for Sarcopenia 2025 criteria. Models adjusted for age, sex, comorbidity, premorbid function, nutritional risk, and inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 136 patients (mean age 78.7\u2009years; 55.1% men), 80 (58.8%) had sarcopenia. After adjustment, a higher profile was associated with higher handgrip strength (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      1.85\u2009kg, 95% CI 0.61\u20133.09), SMI (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      0.30\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI 0.07\u20130.54), and ASM\/BMI (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      0.04, 95% CI 0.01\u20130.07), and lower sarcopenia prevalence (prevalence ratio 0.81 per standard deviation, 95% CI 0.71\u20130.93). Exploratory genus\u2010level signals were most apparent for Agathobacter and Butyricicoccus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A taxonomy\u2010based putative butyrate\u2010producing gut bacteria profile was associated with better admission muscle health in older post\u2010stroke rehabilitation patients. These findings support a gut\u2010muscle phenotype association, not microbial function or causality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ggi.70869","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:20:28Z","timestamp":1791937228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Putative Butyrate\u2010Producing Gut Bacteria Profile and Muscle Health in Older Post\u2010Stroke Patients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-4179","authenticated-orcid":false,"given":"Yoshihiro","family":"Yoshimura","sequence":"first","affiliation":[{"name":"Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5012-056X","authenticated-orcid":false,"given":"Ayaka","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouki","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5871-4018","authenticated-orcid":false,"given":"Fumihiko","family":"Nagano","sequence":"additional","affiliation":[{"name":"Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-0818","authenticated-orcid":false,"given":"Hidetaka","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Tokyo Women's Medical University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-7818","authenticated-orcid":false,"given":"Keisuke","family":"Maeda","sequence":"additional","affiliation":[{"name":"Nutrition Therapy Support Center, Aichi Medical University Hospital  Aichi Japan"},{"name":"Department of Geriatric Medicine Hospital National Center for Geriatrics and Gerontology  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201001004\u2010y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment","volume":"21","author":"Chen L. 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