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In brain, while neuroprotective functions of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>rf2 have been well documented, <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>rf2 contribution to the brain function remains to be elucidated. To address this issue, we investigated whether <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>rf2 deficiency affects psychological behaviors, neurotransmitter systems and gene expressions in mice. We conducted four behavioral tests, social interaction, open\u2010field, rotarod and forced swimming tests and found that <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>rf2<\/jats:italic> knockout mice exhibited reduced immobility in the forced swimming test. Neurochemical analyses revealed that the dopamine and serotonin metabolites increased in the brains of <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>rf2<\/jats:italic> knockout mice. We also present a catalog of genes whose expression is <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>rf2\u2010dependent in brain under unstressed conditions, which includes a number of xenobiotic\u2010metabolizing enzyme genes. These results thus support our contention that <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>rf2 regulates its target genes in brain under unstressed conditions and loss of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>rf2 affects various brain functions.<\/jats:p>","DOI":"10.1111\/gtc.12083","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T09:42:43Z","timestamp":1375090963000},"page":"899-908","source":"Crossref","is-referenced-by-count":36,"title":["Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice"],"prefix":"10.1111","volume":"18","author":[{"given":"Hiroyuki","family":"Muramatsu","sequence":"first","affiliation":[{"name":"Discovery Research Mochida Pharmaceutical Co. 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