{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:41:00Z","timestamp":1784133660285,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>Hyperactivation of Gq signaling causes cardiac hypertrophy, and \u03b2\u2010adrenergic receptor\u2010mediated Gs signaling is attenuated in hypertrophic cardiomyocytes. Here, we found the increase in a global ubiquitination in hypertrophic mouse heart. The activation of Gq signaling resulted in the ubiquitination of G\u03b1s in neonatal rat cardiomyocytes, reduced G\u03b1s expression, and suppressed<jats:styled-content style=\"fixed-case\">cAMP<\/jats:styled-content>response to \u03b2\u2010adrenergic receptor stimulation. Ectopic expression of G\u03b1q induced a similar suppression, which is due to the degradation of G\u03b1s by a ubiquitin\u2013proteasome pathway. Co\u2010expression of Ric\u20108B, a positive regulator of G\u03b1s, effectively canceled the G\u03b1q\u2010induced ubiquitination of G\u03b1s and recovered the<jats:styled-content style=\"fixed-case\">cAMP<\/jats:styled-content>accumulation.<jats:italic>In vitro<\/jats:italic>, G\u03b1q competes for the binding of G\u03b1s to Ric\u20108B. These data show a new role of Ric\u20108B in the crosstalk of two distinct G protein signaling pathways, which are possibly involved in a part of mechanisms of chronic heart failure.<\/jats:p>","DOI":"10.1111\/gtc.12099","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T04:47:16Z","timestamp":1382071636000},"page":"1095-1106","source":"Crossref","is-referenced-by-count":10,"title":["Increased ubiquitination and the crosstalk of<scp>G<\/scp>protein signaling in cardiac myocytes: involvement of<scp>R<\/scp>ic\u20108<scp>B<\/scp>in<scp>G<\/scp>s suppression by<scp>G<\/scp>q signal"],"prefix":"10.1111","volume":"18","author":[{"given":"Riris I","family":"Jenie","sequence":"first","affiliation":[{"name":"Graduate School of Biological Sciences Nara Institute of Science and Technology 8916\u20105 Takayama Ikoma Nara 630\u20100192 Japan"},{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta 55281 Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Graduate School of Biological Sciences Nara Institute of Science and Technology 8916\u20105 Takayama Ikoma Nara 630\u20100192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Kyushu University 3\u20101\u20101 Maidashi Higashi\u2010ku Fukuoka 812\u20108582 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Nakaya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Kyushu University 3\u20101\u20101 Maidashi Higashi\u2010ku Fukuoka 812\u20108582 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norikazu","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Graduate School of Biological Sciences Nara Institute of Science and Technology 8916\u20105 Takayama Ikoma Nara 630\u20100192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Tago","sequence":"additional","affiliation":[{"name":"Graduate School of Biological Sciences Nara Institute of Science and Technology 8916\u20105 Takayama Ikoma Nara 630\u20100192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kurose","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Kyushu University 3\u20101\u20101 Maidashi Higashi\u2010ku Fukuoka 812\u20108582 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[{"name":"Graduate School of Biological Sciences Nara Institute of Science and Technology 8916\u20105 Takayama Ikoma Nara 630\u20100192 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.2.167"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.026"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5363.574"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.34.21253"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.163675"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.15.8121"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"C990","DOI":"10.1152\/ajpcell.2000.279.4.C990","article-title":"Volume overload cardiac hypertrophy exhibits decreased expression of Gs\u03b1 and not of Gi\u03b1 in heart","volume":"279","author":"Fusco F.","year":"2000","journal-title":"Am. 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