{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T01:27:59Z","timestamp":1763429279075},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T00:00:00Z","timestamp":1408320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p><jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content>1\u2010silencing transcription factor (<jats:styled-content style=\"fixed-case\">REST<\/jats:styled-content>), also known as <jats:styled-content style=\"fixed-case\">NRSF<\/jats:styled-content> (neuron\u2010restrictive silencer factor), is a well\u2010known transcriptional repressor of neural genes. <jats:italic>Rest<\/jats:italic> null mice have embryonic lethality which prevents further investigations of the functions of the <jats:italic>Rest<\/jats:italic> gene <jats:italic>in vivo<\/jats:italic>. We studied neonatal but not embryonic lethality that was characterized by gastrointestinal tract dilation in the neural crest cell (<jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>)\u2010specific <jats:italic>Rest<\/jats:italic> conditional knockout (<jats:styled-content style=\"fixed-case\">CKO<\/jats:styled-content>) mice. While no histological abnormalities except the thinning of the digestive tract as a consequence of the gas accumulation were found in the digestive tract of the mutant mice, they do not have proper gastric retention after oral dye administration and the reduction of acetylcholinesterase (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hE) activity in <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>\u2010derived myenteric plexus in the stomach was detected. High <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> concentration in the dilated digestive tract of the <jats:italic>Rest<\/jats:italic>\u00a0<jats:styled-content style=\"fixed-case\">CKO<\/jats:styled-content> mice indicates a failure of gut function by underdeveloped cholinergic transmission in the enteric nervous system. The observed gastrointestinal distension phenotype provides a model for understanding the genetic and molecular basis of <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content> defects in humans.<\/jats:p>","DOI":"10.1111\/gtc.12172","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T02:55:38Z","timestamp":1408416938000},"page":"723-742","source":"Crossref","is-referenced-by-count":7,"title":["Neonatal lethality of neural crest cell\u2010specific <i>Rest<\/i> knockout mice is associated with gastrointestinal distension caused by aberrations of myenteric plexus"],"prefix":"10.1111","volume":"19","author":[{"given":"Hitomi","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science Gifu University Graduate School of Medicine 1\u20101 Yanagido Gifu 501\u20101194 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology Gifu University Graduate School of Medicine 1\u20101 Yanagido Gifu 501\u20101194 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Oomori","sequence":"additional","affiliation":[{"name":"TAIYO NIPPON SANSO Corporation 3054\u20103 Shimokurosawa Takane\u2010cho Hokuto\u2010shi Yamanashi 408\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutake","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Basic Veterinary Science Laboratory of Physiology The United Graduate School of Veterinary Sciences Gifu University 1\u20101 Yanagido Gifu 501\u20101193 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Center for iPS Cell Research and Application (CiRA) Institute for Integrated Cell\u2010Material Sciences (iCeMS) Kyoto University Kyoto 606\u20108507 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kunisada","sequence":"additional","affiliation":[{"name":"Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science Gifu University Graduate School of Medicine 1\u20101 Yanagido Gifu 501\u20101194 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007665"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9873"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.072272"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.148"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.037168"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08347.2002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.12.6496"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00371-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.03.013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593331908616721"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401827101"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.02.059"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01042"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.8.1671"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/2431"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90298-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.074765"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(07)00562-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8971"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00082-3"},{"key":"e_1_2_7_22_1","volume-title":"The Enteric Nervous System","author":"Furness J.B.","year":"2006"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5829"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1604-11.2011"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198106000-00008"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480240207"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/78099"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.02006.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81087-9"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq284"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00495629"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00059"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141319"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060256"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.028548"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.138.6.1343"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200908048"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.080994"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3952494"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511897948"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091611"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01062-10"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076469"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.22.9736-9743.2004"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1005408"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1674"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.9.5791"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3184"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.09.013"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5037-05.2006"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0091-07.2007"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-409"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3214"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.05.026"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7871435"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.21.11369"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01550"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/5007"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-07-0687"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.028"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444303254"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.12.003"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.043"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901010212"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12034"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1454"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8987"}],"container-title":["Genes to Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fgtc.12172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gtc.12172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:08:13Z","timestamp":1696352893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gtc.12172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,18]]},"references-count":66,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/gtc.12172"],"URL":"https:\/\/doi.org\/10.1111\/gtc.12172","archive":["Portico"],"relation":{},"ISSN":["1356-9597","1365-2443"],"issn-type":[{"value":"1356-9597","type":"print"},{"value":"1365-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,18]]}}}