{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T01:29:18Z","timestamp":1771896558387,"version":"3.50.1"},"reference-count":76,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,30]],"date-time":"2014-11-30T00:00:00Z","timestamp":1417305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>During central nervous system development, several guidance cues and receptors, as well as cell adhesion molecules, are required for guiding axons across the midline and along the anterior\u2013posterior axis. In <jats:italic>Drosophila<\/jats:italic>, commissural axons sense the midline attractants Netrin A and B (Net) through Frazzled (Fra) receptors. Despite their importance, lack of <jats:italic>Net<\/jats:italic> or <jats:italic>fra<\/jats:italic> affects only some commissures, suggesting that additional molecules can fulfill this function. Recently, planar cell polarity (PCP) proteins have been implicated in midline axon guidance in both vertebrate and invertebrate systems. Here, we report that the atypical cadherin and PCP molecule Flamingo\/Starry night (Fmi\/Stan) acts jointly with Net\/Fra signaling during midline development. Additional removal of <jats:italic>fmi<\/jats:italic> strongly increases the guidance defects in <jats:italic>Net\/fra<\/jats:italic> mutants. Rescue and domain deletion experiments suggest that Fmi signaling facilitates commissural pathfinding potentially by mediating axonal fasciculation in a partly homophilic manner. Altogether, our results indicate that contact\u2010mediated cell adhesion via Fmi acts in addition to the Net\/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development.<\/jats:p>","DOI":"10.1111\/gtc.12202","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T03:40:27Z","timestamp":1417405227000},"page":"50-67","source":"Crossref","is-referenced-by-count":15,"title":["Flamingo, a seven\u2010pass transmembrane cadherin, cooperates with <scp>N<\/scp>etrin\/<scp>F<\/scp>razzled in <i><scp>D<\/scp>rosophila<\/i> midline guidance"],"prefix":"10.1111","volume":"20","author":[{"given":"Cristina","family":"Organisti","sequence":"first","affiliation":[{"name":"Max Planck Institute of Neurobiology Sensory Neurogenetics Research Group Am Klopferspitz 18 Martinsried 82152 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Hein","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Neurobiology Sensory Neurogenetics Research Group Am Klopferspitz 18 Martinsried 82152 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona C.","family":"Grunwald Kadow","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Neurobiology Sensory Neurogenetics Research Group Am Klopferspitz 18 Martinsried 82152 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Tokyo Institute of Technology Nagatsuta 4259 Midori\u2010ku Yokohama 226\u20108501 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