{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:42:14Z","timestamp":1789530134645,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,15]],"date-time":"2015-11-15T00:00:00Z","timestamp":1447545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>The master clock in the hypothalamic suprachiasmatic nucleus (<jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content>) is assumed to synchronize the tissue\u2010specific rhythms of the peripheral clocks with the environmental day\/night changes via neural, humoral and\/or behavioral connections. The feeding rhythm is considered an important Zeitgeber for peripheral clocks, as daytime feeding reverses (clock) gene rhythms in the periphery, but not in the <jats:styled-content style=\"fixed-case\">SCN<\/jats:styled-content>. In this study, we investigated the necessity of a daily feeding rhythm for maintaining gene expression rhythms in epididymal white adipose tissue (<jats:styled-content style=\"fixed-case\">eWAT<\/jats:styled-content>). We showed that 7 of 9 rhythmic metabolic\/adipokine genes, but not clock genes, lost their rhythmicity upon exposure to 6\u2010meals\u2010a\u2010day feeding. Previously, we showed comparable effects of adrenalectomy on <jats:styled-content style=\"fixed-case\">eWAT<\/jats:styled-content>; therefore, subsequently we investigated the effect of simultaneous disruption of these humoral and behavioral signaling pathways, by exposing adrenalectomized animals to 6\u2010meals\u2010a\u2010day feeding. Interestingly, under these conditions, all the clock genes and 10 of 11 rhythmic metabolic\/adipokine genes lost their rhythmicity. These data indicate that adrenal hormones and feeding rhythm are indispensable for maintaining daily rhythms in metabolic\/adipokine gene, but not clock gene, expression in <jats:styled-content style=\"fixed-case\">eWAT<\/jats:styled-content>. In contrast, at least one of these two signals should be present in order for <jats:styled-content style=\"fixed-case\">eWAT<\/jats:styled-content> clock gene rhythms to be maintained.<\/jats:p>","DOI":"10.1111\/gtc.12315","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T03:50:51Z","timestamp":1447645851000},"page":"6-24","source":"Crossref","is-referenced-by-count":22,"title":["Effects of 6\u2010meals\u2010a\u2010day feeding and 6\u2010meals\u2010a\u2010day feeding combined with adrenalectomy on daily gene expression rhythms in rat epididymal white adipose tissue"],"prefix":"10.1111","volume":"21","author":[{"given":"Yan","family":"Su","sequence":"first","affiliation":[{"name":"Hypothalamic Integration Mechanisms Netherlands Institute for Neuroscience Meibergdreef 47 1105 BA Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewout","family":"Foppen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center (AMC) University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center (AMC) University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Fliers","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center (AMC) University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andries","family":"Kalsbeek","sequence":"additional","affiliation":[{"name":"Hypothalamic Integration Mechanisms Netherlands Institute for Neuroscience Meibergdreef 47 1105 BA Amsterdam The Netherlands"},{"name":"Department of Endocrinology and Metabolism Academic Medical Center (AMC) University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0771"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.050"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5488.2344"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2004.05.001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.137"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199708000-00004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04439.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.4.939"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7970com"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(03)00051-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183500"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00140.2006"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.06.060"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2008.10.006"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.12.026"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M011320"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.08.035"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092250"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2001.00419.x"},{"issue":"4","key":"e_1_2_5_21_1","doi-asserted-by":"crossref","first-page":"S573","DOI":"10.33549\/physiolres.932937","article-title":"Different effects of phase advance and delay in rotating light\u2010dark regimens on clock and natriuretic peptide gene expression in the rat heart","volume":"63","author":"Herichova I.","year":"2014","journal-title":"Physiol. 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