{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T03:34:57Z","timestamp":1787110497347,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Spatiotemporally regulated interaction between the metanephric mesenchyme (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>) and Wolffian duct (<jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>) is essential for the induction of a single ureteric bud (<jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> then interacts with the tip of the <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content> to induce outgrowth and branching of the <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content>, which in turn promotes growth of the adjacent <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>. The Ror family receptor tyrosine kinases, Ror1 and Ror2, have been shown to act as receptors for Wnt5a to mediate noncanonical Wnt signaling. Previous studies have shown that <jats:italic>Ror2\u2010<\/jats:italic>mutant mice exhibit ectopic formation of the <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content>, due to abnormal juxtaposition of the <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> to the <jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content>. We show here that both Ror1 and Ror2 are expressed in the mesenchyme between the <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">WD<\/jats:styled-content> during <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content> formation. Although <jats:italic>Ror1<\/jats:italic>\u2010mutant mice show no apparent defects in <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content> formation, <jats:italic>Ror1;Ror2<\/jats:italic>\u2010double\u2010mutant mice exhibit either defects in <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content> outgrowth and branching morphogenesis, associated with the loss of the <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> from the <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content> domain, or ectopic formation of the <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content>. We also show genetic interactions between <jats:italic>Ror1<\/jats:italic> and <jats:italic>Wnt5a<\/jats:italic> during <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content> formation. These findings suggest that Wnt5a\u2010Ror1\/Ror2 signaling regulates cooperatively the formation of the <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> at the proper position to ensure normal development of the <jats:styled-content style=\"fixed-case\">UB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/gtc.12342","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T16:20:26Z","timestamp":1454516426000},"page":"325-334","source":"Crossref","is-referenced-by-count":17,"title":["Essential role of Wnt5a\u2010Ror1\/Ror2 signaling in metanephric mesenchyme and ureteric bud formation"],"prefix":"10.1111","volume":"21","author":[{"given":"Xiaoyuan","family":"Qi","sequence":"first","affiliation":[{"name":"Division of Cell Physiology Department of Physiology and Cell Biology Graduate School of Medicine Kobe University 7\u20105\u20101 Kusunoki\u2010cho Chuo\u2010ku Kobe Hyogo 650\u20100017 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