{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:16:27Z","timestamp":1740125787354,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports, and Culture of Japan","doi-asserted-by":"crossref","award":["18590254"],"award-info":[{"award-number":["18590254"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Long interspersed element\u20101 (<jats:styled-content style=\"fixed-case\">LINE<\/jats:styled-content>\u20101) is a mammalian transposable element, and its genomic insertion could cause neurological disorders in humans. Incidentally, <jats:styled-content style=\"fixed-case\">LINE<\/jats:styled-content>\u20101 is present in intron 3 of the <jats:italic>microphthalmia\u2010associated transcription factor<\/jats:italic> (<jats:italic>Mitf<\/jats:italic>) gene of the black\u2010eyed white mouse (<jats:italic>Mitf<\/jats:italic><jats:sup><jats:italic>mi\u2010bw<\/jats:italic><\/jats:sup> allele). Mice homozygous for the <jats:italic>Mitf<\/jats:italic><jats:sup><jats:italic>mi\u2010bw<\/jats:italic><\/jats:sup> allele show the white coat color with black eye and deafness. Here, we explored the functional consequences of the <jats:styled-content style=\"fixed-case\">LINE<\/jats:styled-content>\u20101 insertion in the <jats:italic>Mitf<\/jats:italic> gene using homozygous <jats:italic>Mitf<\/jats:italic><jats:sup><jats:italic>mi\u2010bw<\/jats:italic><\/jats:sup> mice on the C3H background (C3H\u2010bw mice) or on the C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 background (bw mice). The open\u2010field test showed that C3H\u2010bw mice moved more irregularly in an unfamiliar environment during the 20\u2010min period, compared to wild\u2010type mice, suggesting the altered emotionality. Moreover, C3H\u2010bw mice showed the lower serum creatinine levels, which may reflect the creatine deficiency. In fact, morphologically abnormal neurons and astrocytes were detected in the frontal cortex of bw mice. The immunohistochemical analysis of bw mouse tissues showed the lower intensity for expression of guanidinoacetate methyltransferase, a key enzyme in creatine synthesis, in neurons of the frontal cortex and in glomeruli and renal tubules. Thus, Mitf may ensure the elongation of axons and dendrites by maintaining creatine synthesis in the frontal cortex.<\/jats:p>","DOI":"10.1111\/gtc.12450","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T14:16:58Z","timestamp":1479133018000},"page":"1365-1379","source":"Crossref","is-referenced-by-count":3,"title":["Microphthalmia\u2010associated transcription factor ensures the elongation of axons and dendrites in the mouse frontal cortex"],"prefix":"10.1111","volume":"21","author":[{"given":"Koji","family":"Ohba","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Applied Physiology Tohoku University School of Medicine Sendai Miyagi 980\u20108575 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Applied Physiology Tohoku University School of Medicine Sendai Miyagi 980\u20108575 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamio","family":"Furuse","sequence":"additional","affiliation":[{"name":"Technology and Development Team for Mouse Phenotype Analysis Japan Mouse Clinic RIKEN BRC Tsukuba Ibaraki 305\u20100074 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Technology and Development Team for Mouse Phenotype Analysis Japan Mouse Clinic RIKEN BRC Tsukuba Ibaraki 305\u20100074 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeharu","family":"Wakana","sequence":"additional","affiliation":[{"name":"Technology and Development Team for Mouse Phenotype Analysis Japan Mouse Clinic RIKEN BRC Tsukuba Ibaraki 305\u20100074 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pathology and Histotechnology Tohoku University Graduate School of Medicine Sendai Miyagi 980\u20108575 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Faculty of Bioscience Nagahama Institute of Bio\u2010Science and Technology Nagahama Shiga 526\u20100829 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Shibahara","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Applied Physiology Tohoku University School of Medicine Sendai Miyagi 980\u20108575 Japan"},{"name":"Faculty of Sports Science Sendai University Shibata\u2010Gun Miyagi 989\u20101693 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