{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:10:45Z","timestamp":1793862645701,"version":"4.6.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23221010"],"award-info":[{"award-number":["23221010"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16H02478"],"award-info":[{"award-number":["16H02478"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007951","name":"Tokyo Medical and Dental University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p><jats:italic>Paternally expressed 11<\/jats:italic>\/<jats:italic>Retrotransposon\u2010like 1<\/jats:italic> (<jats:italic>Peg11<\/jats:italic>\/<jats:italic>Rtl1<\/jats:italic>) knockout (<jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content>) mice show mid\u2010 to late fetal lethality or late fetal growth retardation associated with frequent neonatal lethality. The lethal phenotype is largely dependent on genetic background and becomes more severe with each succeeding generation in the course of backcross experiments to C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 (B6). We previously suggested that these lethal and growth phenotypes in the fetal stages were due to severe defects in placental fetal capillaries in the labyrinth layer. In this study, we re\u2010examined <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> fetuses and placentas and confirmed that the severe clogging of fetal capillaries was associated with <jats:styled-content style=\"fixed-case\">KO<\/jats:styled-content> fetuses showing mid\u2010fetal lethality with internal bleeding. Importantly, the basal region of the fetal capillary network was specifically damaged, also leading to poor expansion of the labyrinth layer and placental size reduction in the later stage. An apparent down\u2010regulation of <jats:italic>transmembrane protein 100<\/jats:italic> (<jats:italic>Tmem100<\/jats:italic>), <jats:italic>mesenchyme homeobox 2<\/jats:italic> (<jats:italic>Meox2<\/jats:italic>) and <jats:italic>lymphatic vessel endothelial hyaluronan receptor 1<\/jats:italic> (<jats:italic>Lyve1<\/jats:italic>) expression were observed in earlier stage placentas even before apparent size reduction became, suggesting that these genes are involved in the maintenance of fetal capillaries associated with <jats:italic>Peg11\/Rtl1<\/jats:italic> during development.<\/jats:p>","DOI":"10.1111\/gtc.12465","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T07:29:00Z","timestamp":1485156540000},"page":"174-188","source":"Crossref","is-referenced-by-count":63,"title":["Severe damage to the placental fetal capillary network causes mid\u2010 to late fetal lethality and reduction in placental size in <i>Peg11\/Rtl1<\/i><scp>KO<\/scp> mice"],"prefix":"10.1111","volume":"22","author":[{"given":"Moe","family":"Kitazawa","sequence":"first","affiliation":[{"name":"Department of Epigenetics Medical Research Institute Tokyo Medical and Dental University (TMDU) 1\u20105\u201045 Yushima Bunkyo\u2010ku Tokyo 113\u20108510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Tamura","sequence":"additional","affiliation":[{"name":"Technology and Development Team for Mouse Phenotype Analysis The Japan Mouse Clinic RIKEN BioResource Center (BRC) 3\u20101\u20101 Koyadai Tsukuba Ibaraki 305\u20100074 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Kaneko\u2010Ishino","sequence":"additional","affiliation":[{"name":"School of Health Sciences Tokai University 143 Shimokasuya Isehara Kanagawa 259\u20101193 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitoshi","family":"Ishino","sequence":"additional","affiliation":[{"name":"Department of Epigenetics Medical Research Institute Tokyo Medical and Dental University (TMDU) 1\u20105\u201045 Yushima Bunkyo\u2010ku Tokyo 113\u20108510 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0773"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/77076"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2006.00103.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.918482"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-55"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1242\/dev.127.21.4719","article-title":"Parental origin\u2010specific developmental defects in mice with uniparental disomy for chromosome 12","volume":"127","author":"Georgiades P.","year":"2000","journal-title":"Development"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2006.4.11"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.13"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30941"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.56"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anngen.2004.03.006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/21892"},{"key":"e_1_2_7_14_1","first-page":"236","article-title":"Use of cryopreservation techniques of embryos and spermatozoa for production of transgenic (Tg) mice and for maintenance of Tg mouse lines","volume":"46","author":"Nakagata N.","year":"1996","journal-title":"Lab. 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