{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:31:04Z","timestamp":1767166264335,"version":"build-2238731810"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012834","name":"Gifu University","doi-asserted-by":"publisher","award":["27KW"],"award-info":[{"award-number":["27KW"]}],"id":[{"id":"10.13039\/100012834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25870292"],"award-info":[{"award-number":["25870292"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rest (RE1\u2010silencing transcription factor, also called Nrsf) is involved in the maintenance of the undifferentiated state of neuronal stem\/progenitor cells by preventing precocious expression of neuronal genes. In order to further investigate the function of\n                    <jats:italic>Rest<\/jats:italic>\n                    in neurons, we generated and examined mice evoking genetic ablation of\n                    <jats:italic>Rest<\/jats:italic>\n                    specifically in neural tissues by generating\n                    <jats:italic>Rest<\/jats:italic>\n                    conditional knockout mice. As the\n                    <jats:italic>Rest<\/jats:italic>\n                    knockout mice are embryonically lethal, we used a\n                    <jats:italic>Sox1\u2010Cre<\/jats:italic>\n                    allele to excise the floxed\n                    <jats:italic>Rest<\/jats:italic>\n                    gene from the early stage of nerve cell differentiation including neural crest\u2010derived nerve cells. Using this conditional\n                    <jats:italic>Rest<\/jats:italic>\n                    knockout\n                    <jats:italic>\n                      Sox1\u2010Cre; Rest\n                      <jats:sup>flox\/flox<\/jats:sup>\n                    <\/jats:italic>\n                    mice, we have revealed the role of\n                    <jats:italic>Rest<\/jats:italic>\n                    in the parasympathetic nervous system in the stomach and heart\n                  <\/jats:p>","DOI":"10.1111\/gtc.12819","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T01:07:19Z","timestamp":1605834439000},"page":"45-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Induced genetic ablation of\n                    <i>Rest<\/i>\n                    leads to the alteration of stimulus\u2010induced response of the vagal nerve"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-9971","authenticated-orcid":false,"given":"Hitomi","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Tissue and Organ Development, Regeneration and Advanced Medical Science Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Physiology Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiko","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Gifu University Hospital Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Physiology Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kunisada","sequence":"additional","affiliation":[{"name":"Department of Tissue and Organ Development, Regeneration and Advanced Medical Science Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007665"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-018-0187-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.072272"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12235"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12172"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163042"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00371-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.03.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310353200"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401827101"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/2431"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90298-8"},{"key":"e_1_2_7_14_1","volume-title":"The enteric nervous system","author":"Furness J. 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