{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:55:42Z","timestamp":1792155342699,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphatic recanalization failure after lymphadenectomy constitutes a major risk of lymphedema in cancer surgery. It has been reported that GATA2, a zinc finger transcription factor, is expressed in lymphatic endothelial cells and is involved in the development of fetal lymphatic vessels. GATA3, another member of the GATA family of transcription factors, is required for the differentiation of lymphoid tissue inducer (LTi) cells and is essential for lymph node formation. However, how GATA2 and GATA3 function in recanalization after the surgical extirpation of lymphatic vessels has not been elucidated. Employing a new model of lymphatic recanalization, we examined the lymphatic reconnection process in <jats:italic>Gata2<\/jats:italic> heterozygous deficient (<jats:italic>Gata2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>) and <jats:italic>Gata3<\/jats:italic> heterozygous deficient (<jats:italic>Gata3<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>) mice. We found that lymphatic recanalization was significantly impaired in <jats:italic>Gata2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice, while <jats:italic>Gata3<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice rarely showed such abnormalities. Notably, the perturbed lymphatic recanalization in the <jats:italic>Gata2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice was partially restored by crossing with the <jats:italic>Gata3<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice. Our results demonstrate for the first time that GATA2 participates in the regeneration of damaged lymphatic vessels and the unexpected suppressive activity of GATA3 against lymphatic recanalization processes.<\/jats:p>","DOI":"10.1111\/gtc.12852","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T09:19:28Z","timestamp":1618651168000},"page":"474-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["GATA2 participates in the recanalization of lymphatic vessels after surgical lymph node extirpation"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-0613","authenticated-orcid":false,"given":"Tomomi","family":"Watanabe\u2010Asaka","sequence":"first","affiliation":[{"name":"Division of Physiology Tohoku Medical and Pharmaceutical University Sendai 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