{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:38:56Z","timestamp":1783442336211,"version":"3.54.6"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autophagy in dopamine (DA) neurons is concerned to be associated with Parkinson's disease (PD), but the detailed mechanism remains unknown. Herein, we aimed to investigate the function of microRNA (miR)\u201029c\u20103p in autophagy in PD models. Intraperitoneal injection of MPTP (20\u00a0mg\/kg) was given to C57BL\/6 mice to establish PD mouse model. SH\u2010SY5Y cells were treated with MPP<jats:sup>+<\/jats:sup> (1\u00a0mmol\/L) to establish in vitro PD model. The results indicated that in the substantia nigra pars compacta (SNpc) DA neurons of PD mice, autophagy was activated accompanied by down\u2010regulated miR\u201029c\u20103p and up\u2010regulated ten\u2010eleven translocation 2 (TET2) expression. Up\u2010regulation of miR\u201029c\u20103p inhibited TET2 expression and SNpc (including DA neurons) autophagy in PD mice. In vitro PD model confirmed that MPP<jats:sup>+<\/jats:sup> treatment markedly down\u2010regulated miR\u201029c\u20103p expression and up\u2010regulated TET2 expression in SH\u2010SY5Y cells in a dose\/time\u2010dependent manner. Moreover, miR\u201029c\u20103p up\u2010regulation also inhibited autophagy and TET2 expression in vitro. Additionally, TET2 was proved to be targeted and down\u2010regulated by miR\u201029c\u20103p. TET2 knockdown inhibited MPP<jats:sup>+<\/jats:sup>\u2010induced autophagy, whereas TET2 over\u2010expression reversed the effects of miR\u201029c\u20103p over\u2010expression on SH\u2010SY5Y cell autophagy. Overall, miR\u201029c\u20103p over\u2010expression inhibits autophagy in PD models, which may be mediated by TET2. Our finding may provide new insights for regulating autophagy to improve PD progression.<\/jats:p>","DOI":"10.1111\/gtc.12877","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T15:52:59Z","timestamp":1622821979000},"page":"684-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["miR\u201029c\u20103p regulates TET2 expression and inhibits autophagy process in Parkinson's disease models"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-8554","authenticated-orcid":false,"given":"Ruili","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Geriatric Neurology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology The Second Affiliated Hospital 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