{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:07Z","timestamp":1787014267413,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K07156"],"award-info":[{"award-number":["17K07156"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02678"],"award-info":[{"award-number":["18H02678"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18KK0433"],"award-info":[{"award-number":["18KK0433"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20cm0106264h0002"],"award-info":[{"award-number":["JP20cm0106264h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer stem cells are a promising target for cancer eradication due to their responsibility for therapy\u2010resistance and cancer recurrence. Previously, we have demonstrated that glioma stem cells (GSCs) recruit and induce the differentiation of bone marrow (BM) monocytes into tumor\u2010infiltrating macrophages, which phagocytose hemorrhaged erythrocytes and store GSC\u2010beneficial iron in mouse xenografts, suggesting a self\u2010expanding strategy of GSCs that exploits host hematopoiesis of myeloid cells. However, it remains unclear whether a self\u2010advantageous effect of GSCs also occurs on erythroid cells during glioma development. Here, we found that, in the primary cultures of mouse fetal liver proerythroblasts (proEs), conditioned media prepared from glioma cells including patient\u2010derived glioblastoma (GBM) cells significantly facilitated the differentiation of proEs into erythroblasts. Importantly, in\u2010vivo erythroid analysis in intracranially GSC\u2010transplanted mice showed an enhanced erythropoiesis in the BM. In addition, the sphere forming ability of patient\u2010derived GBM cells was significantly suppressed by hypoxia treatment and iron chelation, suggesting higher demands of GSCs for oxygen and iron, which may be supplied by GSCs\u2010 and their progeny\u2010induced erythrocyte production. Our findings provide a new insight into survival and expanding strategies of GSCs that systemically exploit host erythropoiesis.<\/jats:p>","DOI":"10.1111\/gtc.12908","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T07:51:05Z","timestamp":1637999465000},"page":"25-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Glioma cells remotely promote erythropoiesis as a self\u2010expanding strategy of cancer stem cells"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-0189","authenticated-orcid":false,"given":"Alapati","family":"Aimaitijiang","sequence":"first","affiliation":[{"name":"Department of Stem Cell Regulation Medical Research Institute Tokyo Medical and Dental University (TMDU) Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Tabu","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Regulation Medical Research Institute Tokyo Medical and Dental University (TMDU) Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Regulation Medical Research Institute Tokyo Medical and Dental University (TMDU) Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Nobuhisa","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Regulation Medical Research Institute Tokyo Medical and Dental University (TMDU) Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Taga","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Regulation Medical Research Institute Tokyo Medical and Dental University (TMDU) Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530110814"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38625-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318022110"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601909356352"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909296106"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812010106"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal5081"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2005.tb00115.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652409788167122"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.253"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1997.00107.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-516252"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041610113"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00073"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12333"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307618100"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.153643"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(00)00006-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.09.003"},{"issue":"10","key":"e_1_2_8_21_1","first-page":"1104","article-title":"Stem cell factor production by human marrow stromal fibroblasts","volume":"23","author":"Linenberger M. 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