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Recent research indicates that microRNAs play a role in the maintenance of gut homeostasis. miR\u2010215 was found to be highly expressed in epithelial cells of the small intestine; however, the involvement of miR\u2010215 in gut immunity remains unknown. Here, we show that miR\u2010215 negatively regulates inflammation in the small intestine by inhibiting CXCL12 production. Mice lacking miR\u2010215\u00a0showed high susceptibility to inflammation induced by indomethacin, accompanied by an increased number of Th17 cells in the lamina propria of the small intestine. Our findings provide a rationale for targeting miR\u2010215 as a therapeutic intervention for inflammatory conditions in the small intestine.<\/jats:p>","DOI":"10.1111\/gtc.12922","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T08:41:15Z","timestamp":1643100075000},"page":"243-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epithelial miR\u2010215 negatively modulates Th17\u2010dominant inflammation by inhibiting CXCL12 production in the small intestine"],"prefix":"10.1111","volume":"27","author":[{"given":"Siddhika","family":"Pareek","sequence":"first","affiliation":[{"name":"Regenerative Medicine Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Sanchenkova","sequence":"additional","affiliation":[{"name":"WPI Immunology Frontier Research Center Osaka University  Osaka 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