{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:35:01Z","timestamp":1784169301337,"version":"3.55.0"},"reference-count":93,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20wm0325003"],"award-info":[{"award-number":["JP20wm0325003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001695","name":"Japan Science and Technology Corporation","doi-asserted-by":"publisher","award":["JPMJCR18S3"],"award-info":[{"award-number":["JPMJCR18S3"]}],"id":[{"id":"10.13039\/501100001695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deficiency in meiotic recombination leads to aberrant chromosome disjunction during meiosis, often resulting in the lethality of gametes or genetic disorders due to aneuploidy formation. Budding yeasts lacking Spo11, which is essential for initiation of meiotic recombination, produce many inviable spores in meiosis, while very rarely all sets of 16 chromosomes are coincidentally assorted into gametes to form viable spores. We induced meiosis in a <jats:italic>spo11<\/jats:italic>\u2206 diploid, in which homolog pairs can be distinguished by single nucleotide polymorphisms and determined whole\u2010genome sequences of their exceptionally viable spores. We detected no homologous recombination in the viable spores of <jats:italic>spo11\u2206<\/jats:italic> diploid. Point mutations were fewer in <jats:italic>spo11<\/jats:italic>\u2206 than in wild\u2010type. We observed <jats:italic>spo11<\/jats:italic>\u2206 viable spores carrying a complete diploid set of homolog pairs or haploid spores with a complete haploid set of homologs but with aneuploidy in some chromosomes. In the latter, we found the chromosome\u2010dependence in the aneuploid incidence, which was positively and negatively influenced by the chromosome length and the impact of dosage\u2010sensitive genes, respectively. Selection of aneuploidy during meiosis II or mitosis after spore germination was also chromosome dependent. These results suggest a pathway by which specific chromosomes are more prone to cause aneuploidy, as observed in Down syndrome.<\/jats:p>","DOI":"10.1111\/gtc.12998","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T07:09:10Z","timestamp":1671433750000},"page":"129-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chromosome\u2010dependent aneuploid formation in Spo11\u2010less meiosis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-0219","authenticated-orcid":false,"given":"Yuri","family":"Kawashima","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Graduate School of Arts and Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3797-4410","authenticated-orcid":false,"given":"Arisa H.","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Graduate School of Arts and Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Hikida","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Graduate School of Arts and Sciences The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Graduate School of Arts and Sciences The University of Tokyo  Tokyo Japan"},{"name":"Universal Biology Institute The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1225739"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025509"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00063-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00098-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00002-10"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.096297.109"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/386414a0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.104.029660"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22707"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.261743.115"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.257"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.207"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.11.2739"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.4.493"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1029"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03374-w"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr330"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81481-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.4.1106-1115.2002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019102924"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.8.3172"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.105.046821"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm1082"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.04.003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.3427"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1500421"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm243"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/35066065"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.04.039"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03279-8"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12138"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03389-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6867735"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz754"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/7050_2007_026"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81876-0"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/96.3.589"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/100.3.387"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/110.2.187"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-12-1223"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1266\/ggs.82.21"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068094"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016634"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.035"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005781"},{"key":"e_1_2_8_47_1","first-page":"1721","article-title":"A study of somatic chromosomes in nine infants with mongolism","volume":"248","author":"Lejeune J.","year":"1959","journal-title":"Comptes Rendus de l'Acad\u00e9mie des Sciences"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.79.3.F223"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr509"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.106.058768"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010047"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.146662.112"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-007-0111-y"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/128.1.79"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-4-r36"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-019-01051-0"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.06.023"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2248-2"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04256-y"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03872"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.21.6177"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.1411"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00434051"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki478"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.2.646"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06913.x"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.009"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.003"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.109.101683"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09529"},{"key":"e_1_2_8_74_1","first-page":"404","article-title":"The frequency of chromosome aberrations in tall men with special reference to 47, XYY and 47, XXY","volume":"28","author":"Philip J.","year":"1976","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03632-x"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-475"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004910"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5309"},{"key":"e_1_2_8_79_1","first-page":"917","article-title":"Meiotic origin of trisomy in confined placental mosaicism is correlated with presence of fetal uniparental disomy, high levels of trisomy in trophoblast, and increased risk of fetal intrauterine growth restriction","volume":"60","author":"Robinson W. P.","year":"1997","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00097-6"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1626608"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1162"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyac106"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-021-01189-w"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.008"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016527"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg028"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142210"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.108.090878"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5196"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90438-3"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8290959"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600138"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002719"}],"container-title":["Genes to Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gtc.12998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/gtc.12998","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gtc.12998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T11:02:28Z","timestamp":1692529348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gtc.12998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,5]]},"references-count":93,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/gtc.12998"],"URL":"https:\/\/doi.org\/10.1111\/gtc.12998","archive":["Portico"],"relation":{},"ISSN":["1356-9597","1365-2443"],"issn-type":[{"value":"1356-9597","type":"print"},{"value":"1365-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,5]]},"assertion":[{"value":"2022-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}