{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:20:20Z","timestamp":1790745620224,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In vivo, cells collectively migrate in a variety of developmental and pathological contexts. Coordinated epithelial rotation represents a unique type of collective cell migrations, which has been modeled in vitro under spatially confined conditions. Although it is known that the coordinated rotation depends on intercellular interactions, the contribution of E\u2010cadherin, a major cell\u2013cell adhesion molecule, has not been directly addressed on two\u2010dimensional (2D) confined substrates. Here, using well\u2010controlled fibronectin\u2010coated surfaces, we tracked and compared the migratory behaviors of MDCK cells expressing or lacking E\u2010cadherin. We observed that wild\u2010type MDCK II cells exhibited persistent and coordinated rotations on discoidal patterns, while E\u2010cadherin knockout cells migrated in a less coordinated manner without large\u2010scale rotation. Our comparison of the collective dynamics between these two cell types revealed a series of changes in migratory behavior caused by the loss of E\u2010cadherin, including a decreased global migration speed, less regularity in quantified coordination, and increased average density of topological defects. Taken together, these data demonstrate that spontaneous initiation of collective epithelial rotations depends on E\u2010cadherin under 2D discoidal confinements.<\/jats:p>","DOI":"10.1111\/gtc.13001","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T13:40:50Z","timestamp":1671802850000},"page":"175-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["E\u2010cadherin\u2010dependent coordinated epithelial rotation on a two\u2010dimensional discoidal pattern"],"prefix":"10.1111","volume":"28","author":[{"given":"Shuangyu","family":"Luo","sequence":"first","affiliation":[{"name":"Graduate School of Biostudies Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanji","family":"Furuya","sequence":"additional","affiliation":[{"name":"Graduate School of Biostudies Kyoto University  Kyoto Japan"},{"name":"Radiation Biology Center Kyoto 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