{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:14:07Z","timestamp":1792012447846,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T00:00:00Z","timestamp":1678579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007877","name":"Fujita Health University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epithelial\u2013mesenchymal transition (EMT) plays a pivotal role in cancer metastasis and treatment resistance, which worsens prognosis. In phase III trials, eribulin improved overall survival in metastatic breast cancer (MBC) patients. In preclinical studies, eribulin suppressed EMT. However, clinical data on the use of eribulin for MBC patients are limited. In this exploratory, prospective study, we examined the effect of eribulin on EMT in MBC patients. Twenty\u2010two patients aged 44\u201382\u2009years with recurrent breast cancer or MBC were treated with eribulin. Breast cancer tissue samples were obtained before treatment and on Day 15\u2009\u00b1\u20095 of the first cycle of eribulin treatment. EMT markers (E\u2010cadherin, claudin\u20103, vimentin, and N\u2010cadherin) were analyzed using western blotting. EMT changes were evaluated based on the ratio of epithelial to mesenchymal markers before and after treatment in individual tumors. E\u2010cadherin\/vimentin, claudin\u20103\/vimentin, E\u2010cadherin\/N\u2010cadherin, and claudin\u20103\/N\u2010cadherin ratios were significantly higher after treatment (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.007, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006, and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.011, respectively). Based on E\u2010cadherin\/vimentin, 65.0% of tumors shifted to an epithelial phenotype, as compared to 66.7% based on claudin\u20103\/vimentin, 84.6% based on E\u2010cadherin\/N\u2010cadherin, and 71.4% based on claudin\u20103\/N\u2010cadherin ratios. Thus, our results showed that eribulin suppressed EMT in breast cancer tissues.<\/jats:p>","DOI":"10.1111\/gtc.13019","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T04:28:30Z","timestamp":1677558510000},"page":"364-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of eribulin on epithelial\u2013mesenchymal transition plasticity in metastatic breast cancer: An exploratory, prospective study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-9733","authenticated-orcid":false,"given":"Takanori","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Biochemistry Fujita Health University School of Medicine  Toyoake Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Japanese Red 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