{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:55:00Z","timestamp":1787885700511,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H05183"],"award-info":[{"award-number":["JP22H05183"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM083016"],"award-info":[{"award-number":["R01GM083016"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM119197"],"award-info":[{"award-number":["R01GM119197"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21ak0101070"],"award-info":[{"award-number":["JP21ak0101070"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dectin\u20101 is a well\u2010characterized C\u2010type lectin receptor involved in anti\u2010fungal immunity through the recognition of polysaccharides; however, molecular mechanisms and outcomes initiated through self\u2010recognition have not been fully understood. Here, we purified a water\u2010soluble fraction from mouse liver that acts as a Dectin\u20101 agonist. To address the physiological relevance of this recognition, we utilized sterile liver inflammation models. The CCl<jats:sub>4<\/jats:sub>\u2010induced hepatitis model showed that Dectin\u20101 deficiency led to reduced inflammation through decreased inflammatory cell infiltration and lower pro\u2010inflammatory cytokine levels. Moreover, in a NASH model induced by streptozotocin and a high\u2010fat diet, hepatic inflammation and fibrosis were ameliorated in Dectin\u20101\u2010deficient mice. The Dectin\u20101 agonist activity was increased in the water\u2010soluble fraction from NASH mice, suggesting a potential pathogenic cycle between Dectin\u20101 activation and hepatitis progression. In vivo administration of the fraction into mice induced hepatic inflammation. These results highlight a role of self\u2010recognition through Dectin\u20101 that triggers hepatic innate immune responses and contributes to the exacerbation of inflammation in pathogenic settings. Thus, the blockade of this axis may provide a therapeutic option for liver inflammatory diseases.<\/jats:p>","DOI":"10.1111\/gtc.13106","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T13:32:39Z","timestamp":1708608759000},"page":"316-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Self\u2010recognition through Dectin\u20101 exacerbates liver inflammation"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4884-3686","authenticated-orcid":false,"given":"Shota","family":"Torigoe","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology, Immunology Frontier Research Center Osaka University  Osaka Japan"},{"name":"Department of Mycobacteriology, Leprosy Research Center National Institute of Infectious Diseases  Tokyo Japan"},{"name":"Management Department of Biosafety, Laboratory Animal and Pathogen Bank National Institute of Infectious Diseases  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Lowman","sequence":"additional","affiliation":[{"name":"Department of Surgery James H. Quillen College of Medicine, East Tennessee State University  Johnson City TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Sugiki","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biophysics Institute for Protein Research, Osaka University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Surgery James H. Quillen College of Medicine, East Tennessee State University  Johnson City TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, Immunology Frontier Research Center Osaka University  Osaka Japan"},{"name":"Department of Molecular Immunology Research Institute for Microbial Diseases, Osaka University  Osaka Japan"},{"name":"Center for Infectious Disease Education and Research (CiDER) Osaka University  Osaka Japan"},{"name":"Division of Molecular Immunology, Medical Mycology Research Center Chiba University  Chiba Japan"},{"name":"Division of Molecular Design, Research Center for Systems Immunology Medical Institute of Bioregulation, Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.72.7.4159-4171.2004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4049-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30506"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.12.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150540"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00251"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169196"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-013-0016-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-013-9468-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0215-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf8271"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2022.09.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1145392"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00639-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.10.59"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.11"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.09.004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1460"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166893"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1957"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.812148"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.80"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-00980-1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082818"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e27"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2842"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677215571192"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.10.058"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.01.008"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.69"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.800847"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.022"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.13"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00893"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9030291"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21655"}],"container-title":["Genes to Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gtc.13106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T10:47:33Z","timestamp":1712141253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gtc.13106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,22]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/gtc.13106"],"URL":"https:\/\/doi.org\/10.1111\/gtc.13106","archive":["Portico"],"relation":{},"ISSN":["1356-9597","1365-2443"],"issn-type":[{"value":"1356-9597","type":"print"},{"value":"1365-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,22]]},"assertion":[{"value":"2024-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}