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Here, we focused on BDNF expression in epididymal WAT (eWAT), a visceral adipose tissue, in mice. During 2\u2009weeks of HFD feeding, <jats:italic>Bdnf<\/jats:italic> mRNA expression in eWAT slightly increased, but a robust increase was observed after 8\u2009weeks of HFD feeding. This upregulation of <jats:italic>Bdnf<\/jats:italic> mRNA was correlated with significant induction of hypoxia\u2010inducible factor 1\u03b1 (<jats:italic>Hif1\u03b1<\/jats:italic>) and platelet\u2010derived growth factor subunit B (<jats:italic>Pdgfb<\/jats:italic>) mRNA in eWAT following 8\u2009weeks of HFD feeding. Furthermore, the increased expression of the M1 macrophage markers was strongly correlated with the elevation of <jats:italic>Bdnf<\/jats:italic> mRNA in the eWAT. Notably, 8\u2009weeks of HFD feeding significantly elevated <jats:italic>Tnf\u03b1<\/jats:italic> mRNA expression in eWAT, while no such induction was observed in inguinal WAT (iWAT). In contrast, the expression of <jats:italic>Adipoq<\/jats:italic> (adiponectin), implicated in improved insulin sensitivity and anti\u2010inflammatory effects, was significantly upregulated in iWAT, but not in eWAT. Thus, our study may show the role of BDNF in eWAT in obesity models, potentially contributing to the pathological state of visceral adipose tissues.<\/jats:p>","DOI":"10.1111\/gtc.13162","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T03:09:55Z","timestamp":1726456195000},"page":"1077-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Accelerated <scp>BDNF<\/scp> expression in visceral white adipose tissues following high\u2010fat diet feeding in mice"],"prefix":"10.1111","volume":"29","author":[{"given":"Kurumi","family":"Sakata","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Neuroscience, Faculty of Pharmacy Takasaki University of Health and Welfare  Takasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-8707","authenticated-orcid":false,"given":"Mamoru","family":"Fukuchi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neuroscience, Faculty of Pharmacy Takasaki University of Health and Welfare  Takasaki 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