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Herein, we investigated how PPAR\u03b3 regulates the expression of the interferon alpha\u2010inducible protein 27\u2010like 2b (\n                    <jats:italic>lfi27l2b<\/jats:italic>\n                    ) gene in the mouse liver. High expression of\n                    <jats:italic>lfi27l2b<\/jats:italic>\n                    was observed in the fatty liver of\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    mice, and the expression was further upregulated by PPAR\u03b3 ligands; however, liver\u2010specific\n                    <jats:italic>Pparg<\/jats:italic>\n                    knockout ameliorated this increase. Moreover, high\n                    <jats:italic>lfi27l2b<\/jats:italic>\n                    expression was observed in the fatty liver of alcohol\u2010fed mice. Reporter assays indicated that the PPAR\u03b3\u2010responsive element (PPRE) is necessary for PPAR\u03b3\u2010dependent induction of\n                    <jats:italic>Ifi27l2b<\/jats:italic>\n                    promoter activities. Furthermore, electrophoretic mobility shift assays showed that PPAR\u03b3 is capable of directly binding the PPRE. Overall, our results indicate that\n                    <jats:italic>lfi27l2b<\/jats:italic>\n                    is a novel PPAR\u03b3 target in the fatty liver.\n                  <\/jats:p>","DOI":"10.1111\/gtc.70049","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:32:43Z","timestamp":1757327563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Transcriptional Regulation of the Interferon Alpha\u2010Inducible Protein\u201027 Like 2b by the Peroxisome Proliferator\u2010Activated Receptor \u03b3\u2002in Fatty Liver Disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Ai","family":"Sakaguchi","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Science Fukuoka University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-1531","authenticated-orcid":false,"given":"Daisuke","family":"Aibara","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Science Fukuoka University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiko","family":"Matsusue","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Science Fukuoka University  Fukuoka 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