{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:48:00Z","timestamp":1789501680216,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K20727"],"award-info":[{"award-number":["24K20727"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K10087"],"award-info":[{"award-number":["24K10087"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K07979"],"award-info":[{"award-number":["23K07979"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005610","name":"Fukuoka University","doi-asserted-by":"publisher","award":["GR2423"],"award-info":[{"award-number":["GR2423"]}],"id":[{"id":"10.13039\/501100005610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatic peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3) promotes fat accumulation in the liver of leptin\u2010deficient (\n                    <jats:italic>ob<\/jats:italic>\n                    \/\n                    <jats:italic>ob<\/jats:italic>\n                    ) mice. However, the mechanism underlying PPAR\u03b3\u2010dependent fat accumulation remains unclear. In this study, we identified miR\u2010205\u20105p as a liver\u2010enriched microRNA regulated by PPAR\u03b3. miR\u2010205\u20105p was significantly upregulated in the\n                    <jats:italic>ob<\/jats:italic>\n                    \/\n                    <jats:italic>ob<\/jats:italic>\n                    mouse livers and induced by treatment with the PPAR\u03b3\u2010specific agonist rosiglitazone. In contrast, its expression was markedly reduced in liver\u2010specific PPAR\u03b3 knockout mice. In both nonalcoholic fatty liver and nonalcoholic steatohepatitis models, hepatic miR\u2010205\u20105p levels were elevated, whereas serum levels were decreased. In HepG2 cells treated with a mixture of oleic and palmitic acids to induce fat accumulation, overexpression of miR\u2010205\u20105p increased the expression of lipogenic gene (\n                    <jats:italic>ACC<\/jats:italic>\n                    ) and decreased the expression of the rate\u2010limiting enzyme for fatty acid \u03b2\u2010oxidation (\n                    <jats:italic>ACOX1<\/jats:italic>\n                    ) and transcription factors involved in fatty acid oxidation and oxidative stress (\n                    <jats:italic>HNF4A<\/jats:italic>\n                    and\n                    <jats:italic>NRF2<\/jats:italic>\n                    ). Furthermore, forced expression of miR\u2010205\u20105p significantly increased fat levels in HepG2 cells. These findings suggest that the PPAR\u03b3\u2010miR\u2010205\u20105p axis plays a key role in the promotion of hepatic fat accumulation. Collectively, our data indicate that miR\u2010205\u20105p has potential as a downstream effector of hepatic PPAR\u03b3 signaling and may serve as a biomarker and therapeutic target for nonalcoholic fatty liver disease.\n                  <\/jats:p>","DOI":"10.1111\/gtc.70079","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T02:35:32Z","timestamp":1766975732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>miR<\/scp>\n                    \u2010205\u20105p Promotes Hepatic Fat Accumulation as a Downstream Effector of\n                    <scp>PPAR\u03b3<\/scp>\n                    Signaling"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6283-8968","authenticated-orcid":false,"given":"Kohei","family":"Matsuo","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Science Fukuoka University  Fukuoka 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