{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:04:35Z","timestamp":1779681875348,"version":"3.53.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The CCR4\u2013NOT complex is a central regulator of post\u2010transcriptional gene expression that controls mRNA deadenylation and decay. Although the catalytic subunits have been well characterized, the physiological roles of several non\u2010catalytic subunits including CNOT11 in mammalian tissues remain incompletely understood. Here, we investigate the physiological role of CNOT11 using genetic mouse models. No homozygous global Cnot11 knockout mice are obtained from heterozygous intercrosses, indicating that CNOT11 is required for early development. We generate hepatocyte\u2010specific Cnot11 knockout mice (Cnot11\u2010LKO) and find that Cnot11\u2010LKO mice exhibit growth retardation and alterations in serum biochemical parameters during early postnatal stages, which are largely resolved by adulthood. Histological analysis does not reveal overt liver injury, while morphological differences in hepatocytes are observed. A marked increase in Ki67\u2010positive cells was observed in the liver of Cnot11\u2010LKO mice relative to control mice. Most Ki67\u2010positive cells express HNF4A, suggesting that hepatocyte maturation is still in progress in the absence of CNOT11. Transcriptomic analyses of early postnatal livers reveal increased expression of cell cycle\u2013related genes and reduced expression of metabolic genes, further supporting delayed liver maturation. These findings suggest that CNOT11 contributes to proper postnatal liver maturation and is required for the timely establishment of metabolically mature hepatocyte functions.<\/jats:p>","DOI":"10.1111\/gtc.70117","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:17:57Z","timestamp":1777371477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver\u2010Specific Deletion of Cnot11 Delays Postnatal Hepatocyte Maturation and Transiently Impairs Liver Function in Mice"],"prefix":"10.1111","volume":"31","author":[{"given":"Saori","family":"Nishijima","sequence":"first","affiliation":[{"name":"Cell Signal Unit Okinawa Institute of Science and Technology Graduate University  Onna, Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of RNA and Gene Regulation, the Institute of Medical Science The University of Tokyo  Minato\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Abe","sequence":"additional","affiliation":[{"name":"Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Bando","sequence":"additional","affiliation":[{"name":"Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-9378","authenticated-orcid":false,"given":"Tadashi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Cell Signal Unit Okinawa Institute of Science and Technology Graduate University  Onna, Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.23018"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2681"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay6912"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.034"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1332"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2011.09.033"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.036"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111902"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.23065"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.01.011"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.168146"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.10.099"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00143"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.6.1427"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2020.5818"}],"container-title":["Genes 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