{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:58:48Z","timestamp":1790305128465,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Epithelial\u2010mesenchymal transition (EMT) is crucial for initiation of cancer metastasis. EMT\u2010induced epithelial cancer cells gain stemness characteristics, which enhance cancer malignancy and chemoresistance. Therefore, it is important to clarify the function of EMT\u2010related genes for development of therapeutics for cancer metastasis. Here, we showed that Signal\u2010transducing adaptor protein\u20102 (STAP\u20102) inhibits EMT in cancer cells through repressing SMAD\u2010mediated ZEB1 expression, which is a master transcription factor of EMT. STAP\u20102 inhibits the interaction between SMAD3 and SMAD4, resulting in the downregulation of SMAD2\/3\/4 complex formation and TGF\u2010\u03b2 signal\u2010induced gene expression. STAP\u20102 expression was repressed by SMAD2\/3\u2010mediated TGF\u2010\u03b2 signals and activated by OVOL1, which is one of the EMT repressor transcription factors. Our study showed that STAP\u20102 is a novel EMT repressor gene which represses ZEB1 expression and motility of cancer cells.<\/jats:p>","DOI":"10.1111\/gtc.70147","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:56:42Z","timestamp":1787983002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Signal Transducing Adaptor Protein\u20102 Represses Epithelial\u2010Mesenchymal Transition by Downregulating\n                    <scp>SMAD<\/scp>\n                    \u2010Mediated\n                    <scp>ZEB1<\/scp>\n                    Expression"],"prefix":"10.1111","volume":"31","author":[{"given":"Fumiya","family":"Okuyama","sequence":"first","affiliation":[{"name":"Laboratory of Mucosal Immunology and Epithelial Biology, Graduate School of Pharmaceutical Sciences Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5998-3855","authenticated-orcid":false,"given":"Yuichi","family":"Kitai","sequence":"additional","affiliation":[{"name":"Laboratory of Mucosal Immunology and Epithelial Biology, Graduate School of Pharmaceutical Sciences Hokkaido University  Sapporo Hokkaido Japan"},{"name":"Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9741-7093","authenticated-orcid":false,"given":"Zhengcheng","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Mucosal Immunology and Epithelial Biology, Graduate School of Pharmaceutical Sciences Hokkaido University  Sapporo Hokkaido 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