{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:11Z","timestamp":1787014271298,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Heavy menstrual bleeding (\n                    <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\n                    ) is a frequent complaint in adolescence. Although\n                    <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\n                    is often caused by immaturity of the hypothalamic\u2010pituitary\u2010ovarian axis, bleeding disorders are another common yet often unidentified cause. The aim of this study was to examine the bleeding patterns and prevalence of inherited bleeding disorders among females referred for\n                    <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\n                    to a multidisciplinary adolescent haematology clinic. We retrospectively reviewed the first 105 patients (ages 8\u201318\u00a0years) referred to this specialty clinic from February 2009 to December 2011. Using menstrual bleeding questionnaires and medical records, data were extracted regarding demographics, bleeding patterns, frequency and types of bleeding disorders identified, and prescribed interventions. Sixty\u2010two per cent of patients were diagnosed with a bleeding disorder, including platelet storage pool deficiency (36%), von Willebrand's disease (9%), other platelet function defect (8%), Ehlers\u2010Danlos syndrome (7%) and combined bleeding disorders (2%). Comparison of the bleeding profiles for females with and without a bleeding disorder revealed only three factors that were significantly different, including the reported regularity of patients' periods (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.02), description of period flow (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0= 0.04) and number of days of each period that the bleeding was described as \u2018heavy\u2019 (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.007). Bleeding disorders are prevalent in adolescent females presenting to a specialty clinic. Specifically, a relatively high proportion of adolescents were diagnosed with platelet storage pool deficiency. In our small population, menstrual bleeding profiles, as examined by a standardized questionnaire, could not identify females with an underlying bleeding disorder, demonstrating the important role of haemostasis testing in the evaluation of adolescents with\n                    <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/hae.12012","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T14:57:29Z","timestamp":1348585049000},"page":"71-75","source":"Crossref","is-referenced-by-count":58,"title":["Menstrual bleeding patterns and prevalence of bleeding disorders in a multidisciplinary adolescent haematology clinic"],"prefix":"10.1111","volume":"19","author":[{"given":"K. T.","family":"Vo","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Ohio State University\/Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Grooms","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology\/BMT Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Klima","sequence":"additional","affiliation":[{"name":"Center for Innovation in Pediatric Practice The Research Institute at Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Holland\u2010Hall","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Ohio State University\/Nationwide Children's Hospital Columbus OH USA"},{"name":"Division of Adolescent Medicine Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Ohio State University\/Nationwide Children's Hospital Columbus OH USA"},{"name":"Division of Pediatric Hematology\/Oncology\/BMT Nationwide Children's Hospital Columbus OH USA"},{"name":"Center for Innovation in Pediatric Practice The Research Institute at Nationwide Children's Hospital Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Management of Anovulatory Bleeding","author":"American College of Obstetricians and Gynecologists","year":"2000"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2009.11.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2010.08.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000148889.15061.fb"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01496.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood.V69.2.454.454","article-title":"Epidemiological investigation of the prevalence of von Willebrand's disease","volume":"69","author":"Rodegheriero F","year":"1987","journal-title":"Blood"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-008-0105-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00434381"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1182\/blood.V33.4.598.598","article-title":"The dense bodies of human platelets: inherent electron opacity of the serotonin storage particles","volume":"33","author":"White JG","year":"1969","journal-title":"Blood"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90009-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-3188(98)70101-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004040100192"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.113042"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2005.00470.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPYMFXZNSNRZ55"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12012","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T18:13:22Z","timestamp":1697307202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,25]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/hae.12012"],"URL":"https:\/\/doi.org\/10.1111\/hae.12012","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,25]]}}}