{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:34:13Z","timestamp":1792251253271,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    von Willebrand disease (\n                    <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>\n                    ) is a bleeding disorder that occurs in up to 1% of the general population. The great majority of females with\n                    <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>\n                    experience menorrhagia. The morbidity burden in females with\n                    <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>\n                    may relate to iron deficiency resulting from menorrhagia. To explore relationships between bleeding disorders, menorrhagia, iron deficiency and the outcomes of health\u2010related quality of life (\n                    <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>\n                    ) and educational attainment. All subjects with\n                    <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>\n                    , and females with other bleeding disorders, in the Canadian national registry who were more than 12\u00a0years of age were eligible for survey. Survey measures included the HEALTH UTILITIES INDEX\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ; abridged Clinical History Assessment Tool; socio\u2010demographic questions and serum ferritin. Statistical analyses included testing differences among groups of means using analysis of variance and of proportions using chi\u2010squared test. Significant size differences in mean\n                    <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>\n                    scores were detected between\n                    <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>\n                    females and both females with other bleeding disorders [diff\u00a0=\u00a0(\u22120.08);\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.017] and\n                    <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>\n                    males [diff\u00a0=\u00a0(\u22120.07);\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.039]. Mean\n                    <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>\n                    scores differed between females with and without menorrhagia (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Mean\n                    <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>\n                    scores were not significantly different between females with and without iron deficiency. Educational attainment was not associated with disease group, menorrhagia status or iron status. Females with\n                    <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>\n                    have a greater morbidity burden than females in the general population, females with other bleeding disorders and males with\n                    <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>\n                    . Menorrhagia is associated with low\n                    <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>\n                    scores in females with bleeding disorders, including\n                    <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>\n                    . Further investigation should assess how menorrhagia impacts\n                    <jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content>\n                    in females with bleeding disorders.\n                  <\/jats:p>","DOI":"10.1111\/hae.12014","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T04:25:21Z","timestamp":1348201521000},"page":"385-391","source":"Crossref","is-referenced-by-count":66,"title":["Bleeding disorders, menorrhagia and iron deficiency: impacts on health\u2010related quality of life"],"prefix":"10.1111","volume":"19","author":[{"given":"C.","family":"Rae","sequence":"first","affiliation":[{"name":"Centre for Health Economics and Policy Analysis Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Furlong","sequence":"additional","affiliation":[{"name":"Centre for Health Economics and Policy Analysis Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton ON Canada"},{"name":"Health Utilities Inc. Dundas ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Horsman","sequence":"additional","affiliation":[{"name":"Centre for Health Economics and Policy Analysis Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton ON Canada"},{"name":"Health Utilities Inc. Dundas ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pullenayegum","sequence":"additional","affiliation":[{"name":"Father Sean O'Sullivan Research Centre Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Demers","sequence":"additional","affiliation":[{"name":"Department of Hematology H\u00f4pital Enfant\u2010Jesus Quebec City QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"St\u2010Louis","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology H\u00f4pital Maisonneuve\u2010Rosemont Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lillicrap","sequence":"additional","affiliation":[{"name":"Department of Pathology Queen's University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Barr","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Pathology and Medicine McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10191"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10327"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02563.x"},{"key":"e_1_2_9_5_1","first-page":"1","article-title":"von Willebrand disease: an introduction for the primary care physician","volume":"47","author":"Lillicrap D","year":"2009","journal-title":"World Federation of Hemophilia Monograph"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01713.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01643.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.00208.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00447.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00342.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649813"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"14","article-title":"Bleeding problems in women","volume":"108","author":"Lee CA","year":"2000","journal-title":"Br J Haematol"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"15","article-title":"Bleeding disorders and pregnancy","volume":"108","author":"Kadir RA","year":"2000","journal-title":"Br J Haematol"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02563.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10093.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03864.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462300101266"},{"key":"e_1_2_9_18_1","first-page":"70","article-title":"Defekt des con Willebrand faktor\u2010proteins. 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