{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:11:45Z","timestamp":1698736305444},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T00:00:00Z","timestamp":1348012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>von Willebrand's disease (<jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>) is the most commonly inherited bleeding disorder. For a long time, it has been said that <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> was absent in some countries due to ethnical differences. Information about the prevalence of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> in Mexico remains unclear, owing largely to poor awareness and diagnosis of the disease. The aim of this study was to objectively diagnose <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> in a cohort of highly selected Mexican patients with a chronic history of bleeding. Mexican Mestizos were recruited between July 2010 and August 2011. Included were 133 adult and paediatric patients with a high suspicion of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>. Fifty\u2010three were diagnosed with <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>: 47 (88.7%) with type 1 <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>, four (7.5%) with type 2a <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> and two (3.8%) with type 3 <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>. Mean age for female patients was 19.5\u00a0years (range 3\u201344\u00a0years) and 18.5\u00a0years (range 4\u201363\u00a0years) for male patients. Mean age at start of bleeding symptoms was 8.8\u00a0years (range 1\u201361). The most frequent clinical symptoms were epistaxis (84.9%), ecchymosis (79.2%), haematomas (71.7%), gum bleeds (62.3%) and petechia (50.9%). Severe transoperative or postoperative bleeding was found in 17 patients (32.1%). Twenty\u2010six women at childbearing age had a history of abnormal gynaecological bleeding. Our results clearly demonstrate the presence of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> in Mexican and underscore the importance of a more detailed description of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>. Efforts to increase the awareness and diagnosis of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> could help in better identification of patients with bleeding disorders and lead to early, appropriate management with safe and efficacious therapies such as desmopressin and plasma concentrates.<\/jats:p>","DOI":"10.1111\/hae.12016","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T08:03:51Z","timestamp":1348041831000},"page":"231-235","source":"Crossref","is-referenced-by-count":6,"title":["von Willebrand's disease in Mexico: a pilot study"],"prefix":"10.1111","volume":"19","author":[{"given":"A.","family":"Majluf\u2010Cruz","sequence":"first","affiliation":[{"name":"UIM Trombosis, Hemostasia y Aterogenesis Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Velez\u2010Ruelas","sequence":"additional","affiliation":[{"name":"Federaci\u00f3n de Hematolog\u00eda A.C Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. I.","family":"Gonzalez\u2010Avila","sequence":"additional","affiliation":[{"name":"Departamento de Hematolog\u00eda, HGR Carlos MacGregor Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Garcia\u2010Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Departamento de Hematolog\u00eda. UMAE Hospital de Especialidades, CMN La Raza Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Berges","sequence":"additional","affiliation":[{"name":"Departamento de Hematolog\u00eda, UMAE Hospital General, CMN La Raza Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Lopez\u2010Santiago","sequence":"additional","affiliation":[{"name":"Departamento de Hematolog\u00eda Instituto Nacional de Pediatr\u00eda Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Monroy\u2010Garcia","sequence":"additional","affiliation":[{"name":"UIM Trombosis, Hemostasia y Aterogenesis Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Moreno\u2010Hernandez","sequence":"additional","affiliation":[{"name":"UIM Trombosis, Hemostasia y Aterogenesis Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Corona\u2010De La Pe\u00f1a","sequence":"additional","affiliation":[{"name":"UIM Trombosis, Hemostasia y Aterogenesis Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Alvarado\u2010Moreno","sequence":"additional","affiliation":[{"name":"UIM Trombosis, Hemostasia y Aterogenesis Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Isordia\u2010Salas","sequence":"additional","affiliation":[{"name":"UIM Trombosis, Hemostasia y Aterogenesis Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hernandez\u2212Juarez","sequence":"additional","affiliation":[{"name":"UIM Trombosis, Hemostasia y Aterogenesis Instituto Mexicano del Seguro Social Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.2.454.454"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80384-1"},{"key":"e_1_2_8_4_1","unstructured":"CarolKK.Von Willebrand Disease. 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