{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:27:53Z","timestamp":1754396873521},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Radiosynovectomy has been performed successfully for more than 10\u00a0years in our hospital. This study investigated the long\u2010term outcome in the context of time to progression (<jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>) analysis and the factors influencing <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> following radiosynovectomy with Re\u2010186 in patients with haemophilic synovitis. Radiosynovectomy performed in 165 joints (81 elbows, 74 ankles, 8 shoulder and 2 hip joints) of 106 patients (median age was 18.0\u00a0\u00b1\u00a07.5\u00a0years; 91 haemophilia A, 13 haemophilia B and 2 von Willebrand's disease between June 2001 and July 2011. The mean follow\u2010up was 48\u00a0months (range: 9\u2013120\u00a0months). This study revealed that patients' mean <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> after primary radiosynovectomy was satisfactory for both the ankle and elbow joints. There was no <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> differences between the ankle and elbow joint groups (67 vs. 72\u00a0months respectively; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.22). We did not find a relationship between the <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> and the following variables: age, type and severity of haemophilia, the presence or absence of inhibitor, the radiological score, range of motion (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>) status of joints and the pretreatment bleeding frequency. In this study, 18\u201320% of the treated joints had improved <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> and 82\u201379% of the treated joints had unchanged <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> after treatment both the ankle and elbow joints respectively. In this report including <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> analysis in the largest series with long\u2010term follow\u2010up, we demonstrated long\u2010term effectiveness of Re\u2010186 radiosynovectomy in haemophilic synovitis. In our experience, the main predictor of outcome following radiosynovectomy is the number of joint bleeding within 6\u00a0months after therapy.<\/jats:p>","DOI":"10.1111\/hae.12059","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T05:52:33Z","timestamp":1353563553000},"page":"275-280","source":"Crossref","is-referenced-by-count":14,"title":["Long\u2010term outcomes in haemophilic synovitis after radiosynovectomy using rhenium\u2010186: a single\u2010centre experience"],"prefix":"10.1111","volume":"19","author":[{"given":"B.","family":"Zulfikar","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Cerrahpasa Medical Faculty Institute of Oncology Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Turkmen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Kilicoglu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Dikici","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bezgal","sequence":"additional","affiliation":[{"name":"Hemophilia Society of Turkey Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Gorgun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Institute of Oncology Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Taser","sequence":"additional","affiliation":[{"name":"Hemophilia Society of Turkey Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2005.20.363"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01691.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01175.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01538.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2005.20.338"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00107.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02276.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197759030-00001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00110.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2006.328"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01406.x"},{"key":"e_1_2_8_13_1","first-page":"29","article-title":"Safety of radiosynovectomy in hemophilic synovitis: it is time to re\u2010evaluate!","volume":"1","author":"Turkmen C","year":"2009","journal-title":"J Coagulation 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