{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:34:25Z","timestamp":1771457665545,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Apical periodontitis (<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>) is an inflammatory lesion around the apex of a tooth caused by bacterial infection of the pulp canal system. <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> appears radiographically as a radiolucent periapical lesion (<jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content>). The elective treatment for teeth with <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> is root canal treatment (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>). No study is available about the frequency of <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> in patients with inherited coagulation disorders (<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>). The aim of this study was to investigate the prevalence of <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> and control subjects. In a cross\u2010sectional study, the radiographic records of 58 patients with haemophilia A, haemophilia B or von Willebrand's disease (study group) and 58 control subjects were examined. The frequency of <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> was assessed using digital panoramic radiographs and the Periapical Index. <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> in one or more teeth was found in 67.2% of patients with <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> and in 48.3% of control subjects (odds ratio\u00a0=\u00a02.20; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.038). At least one <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> was found in 34.5% and 65.5% of subjects in the study and control groups respectively (odds ratio\u00a0=\u00a00.28; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Multivariate logistic regression analysis indicated that subjects with <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> had <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> with higher likelihood than control subjects (odds ratio\u00a0=\u00a07.4; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0005). Patients with <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> disorders showed a significantly higher prevalence of <jats:styled-content style=\"fixed-case\">RPL<\/jats:styled-content> and lower frequency of <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> than control patients.<\/jats:p>","DOI":"10.1111\/hae.12089","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T10:53:19Z","timestamp":1358333599000},"source":"Crossref","is-referenced-by-count":14,"title":["High prevalence of radiolucent periapical lesions amongst patients with inherited coagulation disorders"],"prefix":"10.1111","volume":"19","author":[{"given":"L.","family":"Castellanos\u2010Cosano","sequence":"first","affiliation":[{"name":"Department of Stomatology, School of Dentistry University of Sevilla Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Machuca\u2010Portillo","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry University of Sevilla Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"S\u00e1nchez\u2010Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry University of Sevilla Sevilla Spain"},{"name":"Virgen del Roc\u00edo University Hospital Andalusian Health Service Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Torr\u00e9s\u2010Lagares","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry University of Sevilla Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"L\u00f3pez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Odontostomatology, School of Dentistry University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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