{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:46:37Z","timestamp":1792226797436,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and ultrasonography (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>) are increasingly used in haemophilia A (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>) to detect early joint changes. A total of 40 clinically asymptomatic joints, never involved by bleeding events [\u201chealthy joints\u201d (<jats:styled-content style=\"fixed-case\">HJ<\/jats:styled-content>)], were evaluated by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and, in parallel, by <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> in 20 young subjects with severe <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> (22.45\u00a0\u00b1\u00a02.72\u00a0years old; no history of arthritides, of viral infections or of inhibitors against factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>). The same joints were evaluated in 20 matched non\u2010haemophilic (no\u2010<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>) subjects (mean age 23.90\u00a0\u00b1\u00a02.31\u00a0years, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.078 vs. <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> subjects). <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> images were obtained with specific probe positions according to validated procedures. A validated <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> score and progressive (P\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and additive (A\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scores were employed for data collection and analysis. The <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> score was higher in <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> than in no\u2010<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> subjects (3.40\u00a0\u00b1\u00a01.72 vs. 0.80\u00a0\u00b1\u00a01.10, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Taking into account only moderate\/severe alterations, joint effusion was found in 55% of <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> and in 5% of no\u2010<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> joints (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001); synovial hypertrophy was found in 20% of <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> and in none of the no\u2010<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> joints; cartilage erosion was found in 30% of <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> and in none of no\u2010<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> joints. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> examinations confirmed these findings and the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> score correlated with the A\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.732, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and with the P\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.598, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) scores. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> data significantly correlated as to effusion (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.819, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.002), synovial hypertrophy (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.633, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.036) and cartilage erosion (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.734, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.010). Despite inherent limitations, joint <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> examination identified subclinical abnormalities of <jats:styled-content style=\"fixed-case\">HJ<\/jats:styled-content> in young subjects with severe <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hae.12107","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T08:45:09Z","timestamp":1363596309000},"source":"Crossref","is-referenced-by-count":64,"title":["Magnetic resonance imaging and ultrasound evaluation of \u201chealthy\u201d joints in young subjects with severe haemophilia A"],"prefix":"10.1111","volume":"19","author":[{"given":"M. N. D.","family":"Di Minno","sequence":"first","affiliation":[{"name":"Regional Reference Centre for Coagulation Disorders Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Iervolino","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Soscia","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010morphological and Functional Sciences Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tosetto","sequence":"additional","affiliation":[{"name":"Department of Hematology S. Bortolo Hospital Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Coppola","sequence":"additional","affiliation":[{"name":"Regional Reference Centre for Coagulation Disorders Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schiavulli","sequence":"additional","affiliation":[{"name":"Paediatric Regional Reference Centre for Coagulation Disorders Santobono\u2010Pausilipon Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Marrone","sequence":"additional","affiliation":[{"name":"Regional Reference Centre for Coagulation Disorders Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ruosi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Federico II University Naples 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