{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:30:46Z","timestamp":1761129046743},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T00:00:00Z","timestamp":1364428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Most countries still do not achieve 1\u00a0IU of factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>\/capita sufficient for survival. Although primary prophylaxis prevents synovitis, is not universally used. Chronic synovitis is treated with arthroscopy at expense of considerable amount of coagulation factors, and specialized surgeons. Radioactive synovectomy (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>) is a minimally invasive and cost effective alternative to arthroscopy, often considered first the option for persistent synovitis. Even without established causation with cancer, <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> is avoided by some, due to this concern. We aim contributing to the understanding of <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> safety regarding malignancy, presenting a large number of treated patients, and a single case of cancer. Three centres in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>razil applied <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> with <jats:sup>90<\/jats:sup><jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>ttrium <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>itrate, <jats:sup>90<\/jats:sup><jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>ttrium hydroxyapatite or <jats:sup>153<\/jats:sup><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>amarium hydroxyapatite in haemophilic joints and performed a survey addressing cancer in these patients. Four hundred and eighty eight patients (ages 3\u201351) received 1\u20133 <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> (total 842) and follow\u2010up was 6\u00a0months to 9\u00a0years. One patient aged 14\u00a0years presented <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>wing sarcoma, 11\u00a0months after <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>. The tumour was treated successfully with surgery and chemotherapy. Causality of cancer by <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> is improbable in this case. Accordingly, latency here is far below minimum 5\u201310\u00a0years for radio\u2010induction of solid tumours. Moreover, <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> is not a typically radio\u2010induced tumour, even at high doses. In agreement with others, though recognizing limitations, this study suggests <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> is safe regarding cancer induction. Synovitis is a known burden for patients. The decision of making reasonable usage of <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> should be outweighed with the risks of leaving synovitis untreated.<\/jats:p>","DOI":"10.1111\/hae.12122","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T09:28:39Z","timestamp":1364462919000},"page":"632-636","source":"Crossref","is-referenced-by-count":14,"title":["Radioactive synovectomy with <sup>90<\/sup>yttrium and <sup>153<\/sup>samarium hydroxyapatite in haemophilic joints: preliminary study on radiation safety"],"prefix":"10.1111","volume":"19","author":[{"given":"S.","family":"Thomas","sequence":"first","affiliation":[{"name":"Ambulatorio de Hematologia Hemomat Cuiaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Radiology\/Nuclear Medicine Service Hospital Universit\u00e1rio Clementino Fraga Filho \u2013 Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Souza","sequence":"additional","affiliation":[{"name":"Radiology\/Nuclear Medicine Service Hospital Universit\u00e1rio Clementino Fraga Filho \u2013 Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Lorenzato","sequence":"additional","affiliation":[{"name":"Ambulatorio de Hemofilia HEMEPAR Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. E.","family":"Assi","sequence":"additional","affiliation":[{"name":"Medicina Nuclear IMN Cuiaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. R. L.","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Ambulat\u00f3rio de Orto\u2010hemofilia Hospital de Clinicas da Universidade Federal do Paran\u00e1 Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Ambulatorio de Hemofilia HEMEPAR Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bordim","sequence":"additional","affiliation":[{"name":"Radiology\/Nuclear Medicine Service Hospital Universit\u00e1rio Clementino Fraga Filho \u2013 Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Gutfilen","sequence":"additional","affiliation":[{"name":"Radiology\/Nuclear Medicine Service Hospital Universit\u00e1rio Clementino Fraga Filho \u2013 Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. M. 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