{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:23:38Z","timestamp":1791494618695,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Physical activity and functional ability are important determinants of quality of life and these metrics are affected by both haemophilia and ageing. Outside haemophilic arthropathy, risk factors leading to reduced physical activity and function in people with haemophilia (<jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>) are under\u2010explored. The purpose of this analysis was to determine risk factors for reduced physical activity and functional limitations in <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>. A secondary analysis was conducted on data indexing physical activity and functioning of 88 <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> using data originally collected as part of a cross\u2010sectional study at a single large haemophilia treatment centre. The Framingham Physical Activities Index (<jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content>), the Hemophilia Activities List (<jats:styled-content style=\"fixed-case\">HAL<\/jats:styled-content>) and the Timed Up\u2010and\u2010Go Test (<jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>) were the outcome measures. The World Federation of Haemophilia (<jats:styled-content style=\"fixed-case\">WFH<\/jats:styled-content>) orthopaedic joint score was used as a measure of arthropathy. Multiple linear regression analysis was used to assess the relationship between the outcome measures and covariates. Worsening <jats:styled-content style=\"fixed-case\">WFH<\/jats:styled-content> joint score was independently associated with all three outcome measures (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Increasing age was associated with reduced <jats:styled-content style=\"fixed-case\">PAI<\/jats:styled-content> and increased <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content> time (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The <jats:styled-content style=\"fixed-case\">HAL<\/jats:styled-content> summary score was decreased in patients with chronic liver disease (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.006). The adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> for each model was \u22640.35. This study provides evidence for the relationship between arthropathy and reduced physical functioning\/activity, but also highlights that much of the variation in physical functioning\/activity is not explained by haemophilia\u2010related characteristics.<\/jats:p>","DOI":"10.1111\/hae.12134","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T06:52:37Z","timestamp":1365576757000},"page":"551-557","source":"Crossref","is-referenced-by-count":35,"title":["Physical activity and functional abilities in adult males with haemophilia: a cross\u2010sectional survey from a single <scp>US<\/scp> haemophilia treatment centre"],"prefix":"10.1111","volume":"19","author":[{"given":"J.","family":"Baumgardner","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Rollins School of Public Health Emory University Atlanta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Elon","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Rollins School of Public Health Emory University Atlanta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Antun","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center Atlanta USA"},{"name":"Department of Hematology and Medical Oncology Emory University Atlanta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Emory University Atlanta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center Atlanta USA"},{"name":"Department of Hematology and Medical Oncology Emory University Atlanta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Slovensky","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta Atlanta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.","family":"Kempton","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Emory University Atlanta USA"},{"name":"Aflac Cancer and Blood Disorders Center Emory University Atlanta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-199600240-00005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02200.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02111.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02496.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02417.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb00815.x"},{"key":"e_1_2_8_9_1","first-page":"704","article-title":"Habitual physical activity is not associated with knee osteoarthritis: the Framingham study","volume":"20","author":"Hannan 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