{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:18:30Z","timestamp":1784801910634,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T00:00:00Z","timestamp":1365379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The risk of bleeding in patients with hereditary bleeding disorders (<jats:styled-content style=\"fixed-case\">HBD<\/jats:styled-content>) undergoing gastro\u2010intestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) endoscopic procedures is unknown but guidelines generally recommend correction of factor deficiency. Investigate the safety of oral tranexamic acid (<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content>) without prophylactic factor replacement to prevent bleeding complications in patients with <jats:styled-content style=\"fixed-case\">HBD<\/jats:styled-content> undergoing elective <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> endoscopic procedures. A prospective single\u2010arm pilot study testing the feasibility of using <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content>, without prophylactic factor replacement or <jats:styled-content style=\"fixed-case\">desmopressin<\/jats:styled-content> preprocedure, for prevention of bleeding complications following elective standard risk (&lt;1% risk of bleeding) endoscopic procedures in patients with <jats:styled-content style=\"fixed-case\">HBD<\/jats:styled-content>. Baseline factor levels, haemoglobin and iron studies (<jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>) were measured preprocedure. Primary outcome of bleeding (<jats:styled-content style=\"fixed-case\">NCI CTCAE<\/jats:styled-content> v3.0 Bleeding Scale) was undertaken by patient review and repeat Hb, <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> on day 21. Twenty\u2010eight patients underwent 32 <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> endoscopic procedures from September 2010 until June 2012. The median age was 53\u00a0years (range 24\u201375\u00a0years) and disease types included mild haemophilia A\/B (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), severe haemophilia A\/B (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), von Willebrand disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), FXI deficiency (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) and FVII deficiency (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). Procedures performed included 11 gastroscopies, 12 colonoscopies, 8 gastroscopies and colonoscopies and 1 flexible sigmoidoscopy. Fourteen standard risk procedures and two high risk procedures were performed. Two patients experienced Grade 1 bleeding and one patient experienced Grade 2 bleeding. This study suggests that <jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> without prophylactic factor replacement may be a safe approach for mild and moderate <jats:styled-content style=\"fixed-case\">HBD<\/jats:styled-content> patients undergoing standard risk endoscopic procedures, particularly where no biopsy is performed. These findings should be confirmed in a larger study.<\/jats:p>","DOI":"10.1111\/hae.12146","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T08:07:11Z","timestamp":1365408431000},"page":"583-589","source":"Crossref","is-referenced-by-count":18,"title":["Tranexamic acid without prophylactic factor replacement for prevention of bleeding in hereditary bleeding disorder patients undergoing endoscopy: a pilot study"],"prefix":"10.1111","volume":"19","author":[{"given":"A.","family":"Davis","sequence":"first","affiliation":[{"name":"Ronald Sawers Haemophilia Centre The Alfred Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Ronald Sawers Haemophilia Centre The Alfred Melbourne Vic. 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Street","sequence":"additional","affiliation":[{"name":"Ronald Sawers Haemophilia Centre The Alfred Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Y.","family":"Fong","sequence":"additional","affiliation":[{"name":"Ronald Sawers Haemophilia Centre The Alfred Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Alfred Melbourne Vic. 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