{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:37:12Z","timestamp":1785209832599,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Summary<\/jats:title>The prevalence of obesity in patients with haemophilia (PWH<\/jats:styled-content>) is increasing. We investigated the effect of obesity on bleeding frequency and clotting factor concentrate (CFC<\/jats:styled-content>) usage in PWH<\/jats:styled-content> and assessed whether prothrombotic changes observed in obesity differ between controls and PWH<\/jats:styled-content>. Number of bleeds and CFC<\/jats:styled-content> usage were compared between obese (N<\/jats:italic>\u00a0=\u00a051) and non\u2010obese (N<\/jats:italic>\u00a0=\u00a046) haemophilia A patients. Markers of haemostasis and fibrinolysis were compared between PWH<\/jats:styled-content>, and gender\u2010, age\u2010 and body mass index (BMI<\/jats:styled-content>)\u2010matched non\u2010haemophilic controls (N<\/jats:italic>\u00a0=\u00a091). Median number of bleeds\/patient\u2010month was comparable between obese and non\u2010obese patients with severe haemophilia (P<\/jats:italic>\u00a0=\u00a00.791). Obese patients with severe haemophilia used 1.4 times more CFC<\/jats:styled-content>\/patient\u2010month than non\u2010obese patients (P<\/jats:italic>\u00a0=\u00a00.036). When adjusting for weight this difference disappeared (P<\/jats:italic>\u00a0=\u00a00.451). von Willebrand factor plasma concentration (VWF<\/jats:styled-content>:Ag), factor VIII<\/jats:styled-content> activity and endogenous thrombin potential were higher in obese than in non\u2010obese controls. Obesity did not influence these markers in PWH<\/jats:styled-content>. Plasminogen activator inhibitor type 1 levels were higher in obese vs. non\u2010obese PWH<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.001), whereas levels were comparable between PWH<\/jats:styled-content> and controls (P<\/jats:italic>\u00a0=\u00a00.912). Plasmin\u2010\u03b12\u2010antiplasmin complex (PAP<\/jats:styled-content>) levels appeared to be lower in obese vs. non\u2010obese subjects, both within controls (P<\/jats:italic>\u00a0=\u00a00.011) and PWH<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.008). However, in PWH<\/jats:styled-content>, PAP<\/jats:styled-content> levels were higher than in controls (P<\/jats:italic>\u00a0<\u00a00.001). Obesity is associated with an increase in net CFC<\/jats:styled-content> usage in PWH<\/jats:styled-content>, but has no effect on bleeding frequency. In addition, obesity attenuates hyperfibrinolysis in PWH<\/jats:styled-content>. Future research investigating whether obese PWH<\/jats:styled-content> need CFC<\/jats:styled-content> treatment dosed on weight or whether a lower dosage would suffice to prevent and treat bleedings is needed.<\/jats:p>","DOI":"10.1111\/hae.12182","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T10:52:53Z","timestamp":1368183173000},"page":"744-752","source":"Crossref","is-referenced-by-count":21,"title":["Obesity in haemophilia patients: effect on bleeding frequency, clotting factor concentrate usage, and haemostatic and fibrinolytic parameters"],"prefix":"10.1111","volume":"19","author":[{"given":"A.","family":"Tuinenburg","sequence":"first","affiliation":[{"name":"Van Creveldkliniek\/Department of Hematology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Biere\u2010Rafi","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Emma Children's Hospital, Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Verhamme","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine and Haemostasis University Hospital Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Peerlinck","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine and Haemostasis University Hospital Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. H. A.","family":"Kruip","sequence":"additional","affiliation":[{"name":"Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. A. P.","family":"Laros\u2010Van Gorkom","sequence":"additional","affiliation":[{"name":"Department of Hematology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Roest","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Hematology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C. M.","family":"Meijers","sequence":"additional","affiliation":[{"name":"Department of Experimental Vascular Medicine Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W.","family":"Kamphuisen","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E. G.","family":"Schutgens","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek\/Department of Hematology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61139-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1958.tb03830.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01806.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-9-88"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1457"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02400.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2009.00593.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789X.2002.00056.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04499.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100120068170"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1182\/blood.V94.1.179.413k18_179_185","article-title":"von Willbrand factor propeptide in vascular disorders: a tool to distinguish between acute and chronic endothelial cell perturbation","volume":"94","author":"Mourik JA","year":"1999","journal-title":"Blood"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03786.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.042663"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071636"},{"key":"e_1_2_9_17_1","first-page":"723","article-title":"von Willebrand factor, the endothelium and obesity","volume":"17","author":"Blann AD","year":"1993","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-01-0014"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613566"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050868"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118404"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.28.16603"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.3815.bloodjournal88103815"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616530"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02521.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04431.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12182","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:09:34Z","timestamp":1696338574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,10]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/hae.12182"],"URL":"https:\/\/doi.org\/10.1111\/hae.12182","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,10]]}}}