{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:51:46Z","timestamp":1790175106267,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Haemophilia has been associated with low bone mineral density (BMD). However, prior clinical studies of this population have neither clearly elucidated risk factors for development of low BMD nor identified who may warrant screening for osteoporosis. The aim of the study was to evaluate the relationship between BMD and haemophilic arthropathy and other demographic and clinical variables. We undertook a cross\u2010sectional study of BMD in adult men with haemophilia. Measures of predictor variables were collected by radiographic studies, physical examination, patient questionnaires and review of medical records. Among 88 enrolled subjects, the median age was 41\u00a0years (IQR: 20); median femoral neck BMD (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a087) was 0.90\u00a0g\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    (IQR: 0.24); and median radiographic joint score was 7.5 (IQR: 18). Among subjects &lt;50\u00a0years (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a062), after controlling for BMI, alcohol, HIV and White race, BMD decreased as radiographic joint score increased (est. \u03b2\u00a0=\u00a0\u22120.006\u00a0mg\u00a0cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ; 95% CI \u22120.009, \u22120.003; partial\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.23). Among subjects \u226550\u00a0years (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a026), 38% had osteoporosis (\n                    <jats:italic>T<\/jats:italic>\n                    score less than or equal to \u22122.5) and there was no association between BMD and arthropathy. Risk factors for low BMD in men with haemophilia &lt;50\u00a0years include haemophilic arthropathy, low or normal BMI and HIV. Men with haemophilia over age 50\u00a0years should have routine screening for detection of osteoporosis.\n                  <\/jats:p>","DOI":"10.1111\/hae.12240","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T02:39:13Z","timestamp":1375324753000},"page":"121-128","source":"Crossref","is-referenced-by-count":49,"title":["Bone density in haemophilia: a single institutional cross\u2010sectional study"],"prefix":"10.1111","volume":"20","author":[{"given":"C. L.","family":"Kempton","sequence":"first","affiliation":[{"name":"Department of Haematology and Medical Oncology Emory University School of Medicine Atlanta GA USA"},{"name":"Aflac Cancer and Blood Disorders Center Childrens Healthcare of Atlanta Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Antun","sequence":"additional","affiliation":[{"name":"Department of Haematology and Medical Oncology Emory University School of Medicine Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Antoniucci","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Sutter Pacific Medical Foundation Division of Endocrinology Department of Medicine University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Radiology Emory University School of Medicine Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Haematology and Medical Oncology Emory University School of Medicine Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Haematology and Medical Oncology Emory University School of Medicine Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Slovensky","sequence":"additional","affiliation":[{"name":"Children's Healthcare of Atlanta Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Elon","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Rollins School of Public Health Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2004.00710.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3058"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0629"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02416.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01963.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01405.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-08-05563"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0759-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20877"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.e177"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24184"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32801022eb"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280315"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i12.1843"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09101.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.01.013"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.08.106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1030757"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-6-200209170-00015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0926"},{"key":"e_1_2_9_22_1","volume-title":"Assessment of Osteoporosis at the Primary Health\u2010Care Level","author":"Kanis J","year":"2008"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-9-200805060-00008"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2007.02.007"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb00815.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198006000-00018"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.20.2381"},{"key":"e_1_2_9_28_1","first-page":"704","article-title":"Habitual physical activity is not associated with knee osteoarthritis: the Framingham Study","volume":"20","author":"Hannan MT","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01186.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/80.9.896"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.12.005"},{"key":"e_1_2_9_33_1","unstructured":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. 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