{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:16:03Z","timestamp":1773047763199,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Despite recent advances including new therapeutic options and availability of primary prophylaxis in haemophiliacs, haemophilic synovitis is still the major clinical problem in significant patient population worldwide. We retrospectively reviewed our 10\u2010year experience with Y\u201090 radiosynovectomy to determine the outcome in the knee joints of patients with haemophilic synovitis. Between 2002 and 2012, 82 knee joints of 67 patients with haemophilic synovitis were treated with Y\u201090 radiosynovectomy. The mean age was 16.8\u00a0\u00b1\u00a07.8\u00a0years (range: 5\u201339\u00a0years). The mean follow\u2010up period was 39.6\u00a0\u00b1\u00a025.6\u00a0months (range: 12\u201395\u00a0months). Failure of therapy represented re\u2010bleeding after a radiosynovectomy was used as an end point in patient time to progression (<jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>) analysis. The median <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> was calculated as 72.0\u00a0\u00b1\u00a03.6\u00a0months (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 64.8\u201379.1\u00a0months) in Kaplan\u2013Meier analysis. The 1, 3 and 5\u2010year survival rates were 89%, 73% and 63% respectively. Longer <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> (hazard ratio for progression, 2.5; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.00) was evident in patients who have greater reduction in bleeding frequency within 6\u00a0months after radiosynovectomy. We did not find a relationship between the <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> and the following variables: age, type and severity of haemophilia, the presence or absence of inhibitor, the radiological score, range of motion status of joints and the pretreatment bleeding frequency. We concluded that Y\u201090 radiosynovectomy in knee joint represents an important resource for the treatment of haemophilic synovitis, markedly reducing joint bleeding and long\u2010term durability, irrespective of the radiographic stage and inhibitor status.<\/jats:p>","DOI":"10.1111\/hae.12252","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T12:48:20Z","timestamp":1376311700000},"source":"Crossref","is-referenced-by-count":26,"title":["Survival analysis of Y\u201090 radiosynovectomy in the treatment of haemophilic synovitis of the knee: a 10\u2010year retrospective review"],"prefix":"10.1111","volume":"20","author":[{"given":"C.","family":"Turkmen","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Kilicoglu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Dikici","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bezgal","sequence":"additional","affiliation":[{"name":"Hemophilia Society of Turkey Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kuyumcu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Gorgun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Institute of Oncology Istanbul University Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Taser","sequence":"additional","affiliation":[{"name":"Hemophilia Society of Turkey Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Zulfikar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Cerrahpasa Medical Faculty Institute of Oncology Istanbul University Istanbul 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