{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:34:04Z","timestamp":1771994044198,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Bleeding tendency is weakly correlated with the activity of factor <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>) in the plasma of patients with <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content> deficiency. A laboratory method for predicting bleeding risk in patients with this coagulation disorder is lacking. We investigated whether global coagulation assays, specifically thromboelastography (<jats:styled-content style=\"fixed-case\">TEG<\/jats:styled-content>) and thrombin generation assay (<jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>), could be used to predict bleeding risk. We also sought to identify factors that may explain the differences in bleeding phenotype observed among individuals with severe <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content> deficiency. The study comprised 12 patients with severe <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content> deficiency (<jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content> activity &lt;1%). Eleven patients were homozygous for the Gln100Arg mutation and one patient was compound heterozygous. Clinically, 10 patients had increased haemorrhagic diathesis, whereas two patients were asymptomatic. Blood sampling was performed at baseline for <jats:styled-content style=\"fixed-case\">TEG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content> analyses. The platelet aggregation assay was performed and the plasma level of anticoagulation inhibitors and thrombophilic risk factors assessed. No difference in the <jats:styled-content style=\"fixed-case\">TEG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content> results was observed in all <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>\u2010deficient individuals. The level of free tissue factor pathway inhibitor was within the normal range and similar in symptomatic and asymptomatic subjects. None of the participants had the <jats:styled-content style=\"fixed-case\">FV<\/jats:styled-content> Leiden mutation, prothrombin gene mutation, or abnormal anticoagulant inhibitor levels. Asymptomatic subjects showed normal platelet aggregation. These data suggested that <jats:styled-content style=\"fixed-case\">TEG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content> were not suitable methods for predicting the clinical phenotype in <jats:styled-content style=\"fixed-case\">FVII<\/jats:styled-content>\u2010deficient subjects.<\/jats:p>","DOI":"10.1111\/hae.12256","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T04:34:09Z","timestamp":1377750849000},"page":"141-146","source":"Crossref","is-referenced-by-count":23,"title":["Use of thromboelastography and thrombin generation assay to predict clinical phenotype in patients with severe <scp>FVII<\/scp> deficiency"],"prefix":"10.1111","volume":"20","author":[{"given":"H. T. T.","family":"Tran","sequence":"first","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Haematology Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. E","family":"Tj\u00f8nnfjord","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Haematology Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Holme","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Department of Haematology Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01910.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01844.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029611436196"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00395.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01647.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1225762"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/36HQ36ETU7K8MUXT"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03408.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04291.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-07-0476"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02596.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.074039"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2010.09.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.08.273"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1160\/TH05-06-0407","article-title":"Potential predictors of bleeding risk in inherited factorVII deficiency. Clinical, biological and molecular criteria","volume":"94","author":"Giansily\u2010Blaizot M","year":"2005","journal-title":"Thromb Haemost"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0603-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073575"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2012.06.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00075.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365510600672783"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.01994.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02246.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1182\/blood.V94.11.3960","article-title":"Homozygous Q100R mutations in the second EGF\u2010like domain of factor VII","volume":"94","author":"Kavlie A","year":"1999","journal-title":"Blood"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.14.8516"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1182\/blood.V93.4.1237","article-title":"Characterization of two naturally occurring mutations in the second epidermal growth factor\u2010like domain of factor VII","volume":"93","author":"Hunault M","year":"1999","journal-title":"Blood"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12044"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02748.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029613475473"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613258"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11460"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03767.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-10-0706"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845412Y.0000000068"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2012.724737"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.11.049"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-162453"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1199"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12256","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:28:19Z","timestamp":1695490099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,28]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/hae.12256"],"URL":"https:\/\/doi.org\/10.1111\/hae.12256","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,28]]}}}