{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:23:49Z","timestamp":1760865829388},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with von Willebrand disease (<jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>) may need orthopaedic surgery because of disabling chronic arthropathy due to recurrent joint bleeding. They may also require this surgery independently of their haemostasis disorder. Knowledge regarding the management of orthopaedic surgery in <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> is limited. Description of management of orthopaedic surgery in patients with <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>, based upon retrospective data collection and analysis of 32 orthopaedic procedures carried out over a period of 33\u00a0years in 23 patients was the aim of this study. Of 32 procedures, six were minor (three hand surgery, one foot surgery, two others) and 26 were major (seven joint replacements, nine arthroscopic procedures, two foot surgery, eight others). Twenty\u2010two procedures were performed using replacement therapy with plasma\u2010derived concentrates containing both factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content>) and von Willebrand factor (<jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content>). Two procedures in patients with acquired von Willebrand syndrome (<jats:styled-content style=\"fixed-case\">AWVS<\/jats:styled-content>) were performed using <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> concentrates associated with intravenous immunoglobulins, or desmopressin plus tranexamic acid. Seven procedures were performed using desmopressin alone and one using intravenous immunoglobulins in <jats:styled-content style=\"fixed-case\">AVWS<\/jats:styled-content>. Bleeding complications occurred in seven procedures (22%). In one patient, an anti\u2010<jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> antibody was diagnosed after surgery. Anticoagulant prophylaxis of venous thromboembolism was implemented in four cases only and in two instances there was excessive bleeding. In conclusion, control of surgical haemostasis was achieved in most patients with <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> undergoing orthopaedic surgery. The control of haemostasis combined with an adequate surgical technique and early post\u2010operative rehabilitation are warranted for the successful performance of orthopaedic surgery in <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>, which requires the involvement of specialized haemophilia centres.<\/jats:p>","DOI":"10.1111\/hae.12258","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T04:34:26Z","timestamp":1377750866000},"page":"133-140","source":"Crossref","is-referenced-by-count":29,"title":["Orthopaedic surgery in patients with von Willebrand disease"],"prefix":"10.1111","volume":"20","author":[{"given":"S. M.","family":"Siboni","sequence":"first","affiliation":[{"name":"Angelo Bianchi Bonomi Hemophilia and Thrombosis Center IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Biguzzi","sequence":"additional","affiliation":[{"name":"Angelo Bianchi Bonomi Hemophilia and Thrombosis Center IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. P.","family":"Solimeno","sequence":"additional","affiliation":[{"name":"Ortho\u2010Trauma Unit IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pasta","sequence":"additional","affiliation":[{"name":"Ortho\u2010Trauma Unit IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mistretta","sequence":"additional","affiliation":[{"name":"Angelo Bianchi Bonomi Hemophilia and Thrombosis Center IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Mannucci","sequence":"additional","affiliation":[{"name":"Scientific Direction IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Peyvandi","sequence":"additional","affiliation":[{"name":"Angelo Bianchi Bonomi Hemophilia and Thrombosis Center IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02146.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02507.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00991.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01643.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040403"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01932.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1642471"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199901000-00002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049\u20103848(13)70021\u20105"},{"issue":"2","key":"e_1_2_7_11_1","first-page":"PO054","article-title":"Hemophilia arthropaty occurs in a significant percentage of von Willebrand disease patients","volume":"19","author":"Galen KP","year":"2013","journal-title":"Haemophilia"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164700317393321"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb04598.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2011.10.008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613225"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02758.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.08.265"},{"issue":"2","key":"e_1_2_7_18_1","first-page":"PO026","article-title":"Bleeding complications after arthroscopy in JAK2 positive patient with essential thrombocythemia and acquired von Willebrand syndrome (AVWS)","volume":"19","author":"Rupa\u2010Matysek J","year":"2013","journal-title":"Haemophilia"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200406000-00031"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12258","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:28:26Z","timestamp":1695490106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,28]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/hae.12258"],"URL":"https:\/\/doi.org\/10.1111\/hae.12258","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,28]]}}}