{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:26:09Z","timestamp":1783445169927,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T00:00:00Z","timestamp":1381104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Haemophilia A and B have been associated with increased prevalence of low bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>). However, the utility of bone turnover markers (<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>) remains unknown. The aim of this study was to evaluate bone metabolism in men with haemophilia and to investigate associations between<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>and bone disease. Serum N\u2010 (<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>\u2010I), C\u2010terminal telopeptide of type I collagen (<jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>\u2010I) and tartrate\u2010resistant acid phosphatase band\u20105b (<jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>\u20105b), as bone resorption markers, and osteocalcin (<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>) and bone\u2010specific alkaline phosphatase (b\u2010<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>), as bone formation markers, were assessed. Seventy men with haemophilia A (<jats:italic>n<\/jats:italic>\u00a0=\u00a059) or B (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) were studied. Patients with low<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>had significantly higher b\u2010<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>concentrations compared with those with normal<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>(12.8\u00a0\u00b1\u00a01.60 vs. 9.72\u00a0\u00b1\u00a00.58\u00a0\u03bcg\/L,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009), without any differences in the other<jats:styled-content style=\"fixed-case\">BTM<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>\u2010I and<jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>\u2010I concentrations were negatively associated with oestradiol levels and hip<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>and positively with human immunodeficiency virus infection, number of affected joints and arthropathy scores. B\u2010<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>concentrations were negatively associated with hip<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>, severity of haemophilia and fracture history, and positively with the number of affected joints and testosterone concentrations. After multivariate analysis,<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>\u2010I levels remained negatively associated with oestradiol levels, whereas b\u2010<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>concentrations negatively correlated with the level of physical activity and positively with the number of affected joints. Increased bone metabolism exists in men with haemophilia and low<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>. Increased b\u2010<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>levels may identify patients at high risk for fracture. Increased number of target joints, low physical activity and low oestradiol concentrations are independently associated with increased bone metabolism.<\/jats:p>","DOI":"10.1111\/hae.12271","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:03:34Z","timestamp":1381543414000},"page":"268-275","source":"Crossref","is-referenced-by-count":28,"title":["The clinical utility of bone turnover markers in the evaluation of bone disease in patients with haemophilia A and B"],"prefix":"10.1111","volume":"20","author":[{"given":"P.","family":"Anagnostis","sequence":"first","affiliation":[{"name":"Haemophilia Centre of Northern Greece Second Propedeutic Department of Internal Medicine Aristotle University of Thessaloniki Hippokration Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vakalopoulou","sequence":"additional","affiliation":[{"name":"Haemophilia Centre of Northern Greece Second Propedeutic Department of Internal Medicine Aristotle University of Thessaloniki Hippokration Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u2010A.","family":"Vyzantiadis","sequence":"additional","affiliation":[{"name":"First Department of Microbiology Medical School Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Charizopoulou","sequence":"additional","affiliation":[{"name":"Department of Psychology School of Philosophy Aristotle University Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Karras","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Agios Pavlos General Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. G.","family":"Goulis","sequence":"additional","affiliation":[{"name":"Unit of Reproductive Endocrinology First Department of Obstetrics and Gynecology Medical School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Karagiannis","sequence":"additional","affiliation":[{"name":"Haemophilia Centre of Northern Greece Second Propedeutic Department of Internal Medicine Aristotle University of Thessaloniki Hippokration Hospital Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gerou","sequence":"additional","affiliation":[{"name":"Laboratories \u201cAnalysis\u201d Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Garipidou","sequence":"additional","affiliation":[{"name":"Haemophilia Centre of Northern Greece Second Propedeutic Department of Internal Medicine Aristotle University of Thessaloniki Hippokration 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