{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:48:45Z","timestamp":1791125325493,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To evaluate outcome of prophylactic clotting factor replacement in children with haemophilia, the Haemophilia Joint Health Score (<jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>) was developed aiming at scoring early joint changes in children aged 4\u201318. The <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content> has been used for adults on long\u2010term prophylaxis but interpretation of small changes remains difficult. Some changes in these patients may be due to sports\u2010related injuries. Evaluation of <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content> score in healthy adults playing sports could improve the interpretation of this score in haemophilic patients. The aim of this study was to evaluate the <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content> scores in a cohort of young, healthy men participating in sports. Concomitant with a project collecting <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> images of ankles and knees in normal young adults, <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content> scores were assessed in 30 healthy men aged 18\u201326, participating in sports one to three times per week. One physiotherapist assessed their clinical function using the <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content> 2.1. History of joint injuries was documented. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> images were scored by a single radiologist, using the International Prophylaxis Study Group additive <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> score. Median age of the study group was 24.3\u00a0years (range 19.0\u201326.4) and median frequency of sports activities was three times per week (range 1\u20134). Six joints (five knees, one ankle) had a history of sports\u2010related injury. The median overall <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content> score was 0 out of 124 (range 0\u20133), with 60% of subjects showing no abnormalities on <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>. All joints were normal on <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. These results suggest that frequent sports participation and related injuries are not related with abnormalities in <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content> scores.<\/jats:p>","DOI":"10.1111\/hae.12290","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T08:02:13Z","timestamp":1382688133000},"page":"282-286","source":"Crossref","is-referenced-by-count":33,"title":["Haemophilia Joint Health Score in healthy adults playing sports"],"prefix":"10.1111","volume":"20","author":[{"given":"D.","family":"Sluiter","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Nursing Science and Sports UMC Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Foppen","sequence":"additional","affiliation":[{"name":"Department of Radiology UMC Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"de Kleijn","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Nursing Science and Sports UMC Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fischer","sequence":"additional","affiliation":[{"name":"van Creveldkliniek Department of Haematology UMC Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00599.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00757.x"},{"key":"e_1_2_9_4_1","first-page":"1740","article-title":"Articular cartilage is more susceptible to blood induced damage at young that at old age","volume":"27","author":"Roosendaal G","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199607000-00003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00694.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01953.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01312.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20353"},{"issue":"2","key":"e_1_2_9_11_1","first-page":"3","article-title":"Prophylaxis: musculoskeletal evaluation","volume":"30","author":"Gilbert MS","year":"1993","journal-title":"Semin Hematol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12197"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2450\/2012.0091\u201012."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02513.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2012.01750.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-470898"},{"issue":"2","key":"e_1_2_9_17_1","first-page":"79","article-title":"Joint health status of Chinese hemophilia children: a pilot study using the Hemophilia Joint Health Assessment Scale (HJHS)","volume":"14","author":"Chen L","year":"2008","journal-title":"Haemophilia"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02178.x"},{"key":"e_1_2_9_19_1","first-page":"1","article-title":"Physical fitness, functional ability and quality of life in children with severe haemophilia: a pilot study","volume":"12","author":"Net J","year":"2006","journal-title":"Haemophilia"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12191"},{"key":"e_1_2_9_21_1","unstructured":"HJHS 2.1 Instruction manual. 2006. Available athttp:\/\/ipsg.ca\/working-groups\/physical-therapy. Accessed July 29 2013."},{"key":"e_1_2_9_22_1","volume-title":"Joint Motion: Methods of Measuring and Recording","author":"American Academy of Orthopaedic Surgeons","year":"1965"},{"key":"e_1_2_9_23_1","volume-title":"The Clinical Measurement of Joint Motion","author":"Green WB","year":"1994"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02399.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01049.x"},{"key":"e_1_2_9_26_1","unstructured":"Sportblessures.Blessurecijfers VeiligheidNL. 2012. Available athttp:\/\/www.veiligheid.nl\/csi\/veiligheidnl.nsf\/0\/D25BD7C89FA24AA3C1257B4200481C3A\/&#x0024;file\/Cijfersfactsheet%20Sportblessures%20algemeen.pdf. Accessed July 29 2013."},{"key":"e_1_2_9_27_1","unstructured":"CBS.Vrije tijd; sport hobby cultuur recreatie vakantie. 2012. 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