{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:57:33Z","timestamp":1773518253051,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Platelet function defects (<jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content>) are reported to occur frequently in adult women with heavy menstrual bleeding (<jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>). Few studies on adolescent <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content> report varying incidence rates (2\u201344%) for <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content>. We reviewed our institutional experience in detecting and managing <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content> in adolescent <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>. Postmenarchial girls and adolescents with <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content> seen at our institution undergo a comprehensive bleeding disorder work\u2010up by paediatric haematology and paediatric gynaecology providers. Whole blood platelet aggregometry (<jats:styled-content style=\"fixed-case\">WBPA<\/jats:styled-content>) is performed as a second tier test after excluding thrombocytopaenia, coagulation factor deficiencies and Von Willebrand disease (<jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>). We retrospectively reviewed the medical records of adolescents with <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content> seen between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>une 2009 and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2010, as approved by the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nstitutional <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>eview <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>oard. Patient demographics, clinical features, laboratory results, therapy details and patient outcome information were analysed. Overall, 114 postmenarchial girls and adolescents with <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content> were evaluated; 68 patients (59%) had <jats:styled-content style=\"fixed-case\">WBPA<\/jats:styled-content> study performed. Nineteen patients (28%) had at least one aggregation or secretion defect; 12 (18%) had two or more such defects. Treatment included hormonal therapy (13\/19; 68%), antifibrinolytic agents (8\/19; 42%) and intra\u2010nasal <jats:styled-content style=\"fixed-case\">DDAVP<\/jats:styled-content> (3\/19; 16%). Thirteen patients (81%) had improved outcome (median follow\u2010up \u2013 15.6\u00a0months; range of 1\u201366\u00a0months). In this study, <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content> were identified in nearly one\u2010third of girls with <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>, with the majority of these having two or more defects as identified by <jats:styled-content style=\"fixed-case\">WBPA<\/jats:styled-content>. Further prospective studies are needed to better define the prevalence and address appropriate management of <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content> and other bleeding complications of <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content> in adolescents.<\/jats:p>","DOI":"10.1111\/hae.12293","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T07:57:02Z","timestamp":1384934222000},"page":"249-254","source":"Crossref","is-referenced-by-count":33,"title":["Platelet function defects in adolescents with heavy menstrual bleeding"],"prefix":"10.1111","volume":"20","author":[{"given":"H. L.","family":"Mills","sequence":"first","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston TX"},{"name":"Section of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Abdel\u2010Baki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston TX"},{"name":"Section of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Teruya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston TX"},{"name":"Section of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Houston TX"},{"name":"Division of Transfusion Medicine Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston TX"},{"name":"Department of Obstetrics &amp; Gynecology Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston TX"},{"name":"Section of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"D.","family":"Mahoney","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston TX"},{"name":"Section of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. L.","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston TX"},{"name":"Section of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. V.","family":"Srivaths","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine Houston TX"},{"name":"Section of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Houston TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02382.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000148889.15061.fb"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90009-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2005.00470.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01496.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.113042"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2008.12.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2012.07.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2012.01.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.00208.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00061.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004040100192"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-3188(98)70101-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2012.01.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2009.11.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP9V3RRVNZMKDS"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5482\/ha-1133"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2012.724737"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2010.485256"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2010.11.004"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12293","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:27:25Z","timestamp":1695569245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,20]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/hae.12293"],"URL":"https:\/\/doi.org\/10.1111\/hae.12293","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,20]]}}}