{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:05:33Z","timestamp":1772035533558,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T00:00:00Z","timestamp":1385683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Spontaneous haemorrhage in patients with haemophilia is generally considered to occur randomly and without a predictable temporal or seasonal pattern; however, there is a lack of evidence in the literature on the effects of weather, temperature and atmosphere on bleeding episodes. This <jats:italic>post hoc<\/jats:italic> analysis of a multicentre, open\u2010label crossover study examined the influence of seasonality on bleeding frequency and patient\u2010assessed pain in patients with moderately severe and severe (<jats:styled-content style=\"fixed-case\">FIX<\/jats:styled-content> C\u00a0\u2264\u00a02%) haemophilia B. Fifty patients were enrolled and treated on\u2010demand for 16\u00a0weeks; 47 were subsequently randomized to one of two prophylactic regimens (nonacog alfa 100\u00a0IU\u00a0kg<jats:sup>\u22121<\/jats:sup> once weekly or 50\u00a0IU\u00a0kg<jats:sup>\u22121<\/jats:sup> twice weekly) for 16\u00a0weeks. Patients then underwent an 8\u2010week washout period of on\u2010demand therapy before being crossed over to the other prophylactic regimen for 16\u00a0weeks. Bleeding episodes during the on\u2010demand treatment periods were analysed. To assess for temporal trends, data were graphed as scatter plots. The primary end point was the annualized bleeding rate (<jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>). Additional measures included raw and median pain scores during every joint bleeding event (spontaneous or traumatic), with pain scored using the Brief Pain Inventory (0\u00a0=\u00a0\u2018no pain\u2019 to 10\u00a0=\u00a0\u2018pain as bad as you can imagine\u2019). The observed <jats:styled-content style=\"fixed-case\">ABR<\/jats:styled-content>s during the on\u2010demand periods showed no distinguishable trend over time. Analysis of pain associated with joint bleeding episodes also did not demonstrate any discernible temporal trend. No apparent seasonal variation in bleeding pattern or patient\u2010reported pain was observed in this analysis of patients with haemophilia B.<\/jats:p>","DOI":"10.1111\/hae.12305","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T11:50:51Z","timestamp":1385725851000},"page":"349-353","source":"Crossref","is-referenced-by-count":7,"title":["Lack of seasonal variation in bleeding and patient\u2010assessed pain patterns in patients with haemophilia B receiving on\u2010demand therapy"],"prefix":"10.1111","volume":"20","author":[{"given":"F.","family":"Shafer","sequence":"first","affiliation":[{"name":"Pfizer Inc Collegeville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Pfizer Inc Collegeville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Vendetti","sequence":"additional","affiliation":[{"name":"Pfizer Inc Collegeville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Rendo","sequence":"additional","affiliation":[{"name":"Pfizer Inc Collegeville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Carr","sequence":"additional","affiliation":[{"name":"Pfizer Inc Collegeville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02909.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615621"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02770.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1973.tb01680.x"},{"key":"e_1_2_8_6_1","first-page":"659","article-title":"[Meteorologic effects on hemorrhagic diathesis in hemophilia. 2. Weather effects on hemophilia with special reference to the atmospheric temperature\u2010humidity complex]","volume":"45","author":"Linde P","year":"1990","journal-title":"Z Gesamte Inn Med"},{"key":"e_1_2_8_7_1","first-page":"631","article-title":"[Recommendations for a medical\u2010meteorologic prognosis for hemophilia]","volume":"117","author":"Linde P","year":"1990","journal-title":"Folia Haematol Int Mag Klin Morphol Blutforsch"},{"key":"e_1_2_8_8_1","first-page":"218","article-title":"[Bleeding in hemophilia as a function of meteorologic changes and the effect of tissue hormones]","volume":"43","author":"Katanic D","year":"1990","journal-title":"Med Pregl"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5777.771"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.12727"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02450.x"},{"key":"e_1_2_8_12_1","unstructured":"ValentinoLA PlushchOP RusenLet\u00a0al.A multicenter randomized open\u2010label study to compare on\u2010demand treatment with two prophylaxis regimens of recombinant coagulation factor IX in subjects with hemophilia B [poster]. Presented at: Biennial Congress of the International Society on Thrombosis and Haemostasis Kyoto Japan July 23\u201028 2011."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90143-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1300953"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02838.x"},{"key":"e_1_2_8_16_1","first-page":"169","article-title":"Prophylaxis for adults with haemophilia: one size does not fit all","volume":"10","author":"Fischer K","year":"2012","journal-title":"Blood Transfus"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02709.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)90161-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1182\/blood.V120.21.625.625","article-title":"Rapid, high resolution joint ultrasound reveals frequent discrepancies in the clinical management of painful joint and tissue events in symptomatic adults with hemophilia [abstract]","volume":"120","author":"Ceponis A","year":"2012","journal-title":"Blood"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.12305","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:14:34Z","timestamp":1695543274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,29]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/hae.12305"],"URL":"https:\/\/doi.org\/10.1111\/hae.12305","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,29]]}}}