{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:35:15Z","timestamp":1778200515768,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>There is a paucity of literature on haemophilia treatment in Latin American countries, a region characterized by rapidly improving systems of care, but with substantial disparities in treatment between countries. The aim of this study was to evaluate the musculoskeletal status of haemophilia patients from Latin America and to examine the relationship between musculoskeletal status and treatment practices across countries. The Committee of Latin America on the Therapeutics of Inhibitor Groups conducted a survey of its member country representatives on key aspects of haemophilia treatment in 10 countries. Musculoskeletal status of patients was obtained during routine comprehensive evaluations between March 2009 and March 2011. Eligible patients had severe haemophilia A (factor VIII &lt;1%) without inhibitors (&lt;0.6\u00a0BU\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>) and were \u22655\u00a0years of age. Musculoskeletal status was compared between three groups of countries, based primarily on differences in the availability of long\u2010term prophylaxis. Overall, 143 patients (5\u201366\u00a0years of age) were enrolled from nine countries. In countries where long\u2010term prophylaxis had been available for at least 10\u00a0years (Group A), patients aged 5\u201310\u00a0years had significantly better mean World Federation of Hemophilia clinical scores, fewer target joints and fewer affected joints than patients from countries where long\u2010term prophylaxis has been available for about 5\u00a0years (Group B) or was not available (Group C). In Latin America, the musculoskeletal status of patients with severe haemophilia without inhibitors has improved significantly in association with the provision of long\u2010term prophylaxis. As more countries in Latin America institute this practice, further improvements are anticipated.<\/jats:p>","DOI":"10.1111\/hae.12316","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T07:30:01Z","timestamp":1387524601000},"source":"Crossref","is-referenced-by-count":7,"title":["Musculoskeletal evaluation in severe haemophilia A patients from Latin America"],"prefix":"10.1111","volume":"20","author":[{"given":"M. C.","family":"Ozelo","sequence":"first","affiliation":[{"name":"Unidade de Hemofilia IHTC \u2018Claudio L. P. Correa\u2019 Instituto Nacional de Tecnologia do Sangue Hemocentro UNICAMP University of Campinas Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. R.","family":"Villa\u00e7a","sequence":"additional","affiliation":[{"name":"Centro de Hemofilia S\u00e3o Paulo Brazil"},{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"P\u00e9rez\u2010Bianco","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematologicas \u2018Mariano Castex\u2019 Academia Nacional de Medicina Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Candela","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematologicas \u2018Mariano Castex\u2019 Academia Nacional de Medicina Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Garcia\u2010Chavez","sequence":"additional","affiliation":[{"name":"Unidad Medica de Alta Especialidad Centro M\u00e9dico Nacional La Raza Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Moreno\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda Hospital del Ni\u00f1o Panama City Panama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centro de Hemofilia S\u00e3o Paulo Brazil"},{"name":"Hospital das Clinicas da Universidade de S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Rodriguez\u2010Grecco","sequence":"additional","affiliation":[{"name":"Centro Hospitalario Pereira Rossell Hospital de Clinicas Montevideo Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Solano","sequence":"additional","affiliation":[{"name":"Hospital de San Jose Fundacion Universitaria de Ciencias de la Salud Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Chumpitaz","sequence":"additional","affiliation":[{"name":"Hospital Nacional Edgardo Rebagliati M. Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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